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人 IL-1 alpha / IL1A / IL1F1 HEK293 过表达细胞裂解液 (阳性对照)

产品数据评论实验方法
描述: Active  
表达宿主: Human Cells  
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10128-HNCH-5
10128-HNCH-20
10128-HNCH-100
5 µg 
20 µg 
100 µg 
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描述: Active  
表达宿主: E. coli  
  • Slide 1
50114-MNAE-5
50114-MNAE-20
50114-MNAE-100
5 µg 
20 µg 
100 µg 
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反应性: Human  
应用 : ELISA  
    10128-T16-50
    10128-T16-200
    10128-T16-100
    50 µg 
    200 µg 
    100 µg 
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    反应性: Human  
    应用 : ELISA  
      10128-R004-50
      10128-R004-100
      50 µg 
      100 µg 
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      反应性: Human  
      应用 : ELISA  
        10128-RP01-400
        10128-RP01-200
        10128-RP01-100
        400 µg 
        200 µg 
        100 µg 
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        反应性: Mouse  
        应用 : ELISA  
          50114-R024-50
          50114-R024-100
          50 µg 
          100 µg 
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          反应性: Mouse  
          应用 : 
            50114-R148-50
            50114-R148-100
            50114-R148-1
            50 µg 
            100 µg 
            1 mg 
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            反应性: Mouse  
            应用 : ELISA  IHC-P  
            • Slide 1
            50114-RP02-50
            50114-RP02-200
            50114-RP02-100
            50 µg 
            200 µg 
            100 µg 
            Add to Cart
            反应性: Mouse  
            应用 : ELISA  
              50114-RP01-400
              50114-RP01-200
              50114-RP01-100
              400 µg 
              200 µg 
              100 µg 
              Add to Cart
              反应性: Mouse  
              应用 : 
              • Slide 1
              • Slide 1
              50114-T52-50
              50114-T52-200
              50114-T52-100
              50 µg 
              200 µg 
              100 µg 
              Add to Cart
              反应性: Mouse  
              应用 : ELISA  
                50114-T16-50
                50114-T16-200
                50114-T16-100
                50 µg 
                200 µg 
                100 µg 
                Add to Cart

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                IL1A/IL-1A/IL-1F1 lysate_category 研究背景

                IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. Cytokines can be classified into two groups: pro- and anti-inflammatory. Pro-inflammatory cytokines, including IFNgamma, IL-1, IL-6 and TNF-alpha, are predominantly derived from the innate immune cells and Th1 cells. Anti-inflammatory cytokines, including IL-10, IL-4, IL-13 and IL-5, are synthesized from Th2 immune cells. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. It is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity.

                Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

                 IL1A/IL-1A/IL-1F1 lysate_category 参考资料
              • Nicklin MJ,et al. (1994) A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes. Genomics. 19(2):382-4.
              • March CJ, et al. (1985) Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature. 315(6021):641-7.
              • Bankers-Fulbright JL, et al. (1996) Interleukin-1 signal transduction. Life Sci. 59(2):61-83.
              • Dinarello CA, et al. (1997) Induction of interleukin-1 and interleukin-1 receptor antagonist. Semin Oncol. 24 (3 Suppl 9):S9-81-S9-93.
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