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小鼠 BDNF/ANON2 基因ORF全长cDNA克隆(表达载体), C-His 标签

产品数据评论实验方法
描述: Active  
表达宿主: CHO Stable Cells  
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50240-MNAS-5
50240-MNAS-20
5 µg 
20 µg 
Add to Cart
反应性: Human  
应用 : 
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100863-T08-50
100863-T08-200
100863-T08-100
50 µg 
200 µg 
100 µg 
Add to Cart
反应性: Mouse  
应用 : ELISA  
    50240-RP01-200
    50240-RP01-100
    200 µg 
    100 µg 
    Add to Cart
    反应性: Mouse  
    应用 : ELISA  WB  
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    50240-T48-50
    50240-T48-100
    50 µg 
    100 µg 
    Add to Cart

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    BDNF/ANON2 cdna-clone 研究背景

    BDNF is a member of the nerve growth factor family. It is highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. It also can be detected in heart, lung, skeletal muscle, testis, prostate and placenta. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. During development, BDNF promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. It participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. It functions as the major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.

    小鼠 BDNF/ANON2 cdna-clone 参考资料
  • Zigova T, et al. (1998) Intraventricular administration of BDNF increases the number of newly generated neurons in the adult olfactory bulb. Mol Cell Neurosci. 11(4):234-45.
  • Acheson A, et al. (1995) A BDNF autocrine loop in adult sensory neurons prevents cell death. Nature 374(6521):450-3.
  • Bekinschtein P, et al. (2008) BDNF is essential to promote persistence of long-term memory storage. Proc Natl Acad Sci. 105(7):2711-6.
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