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人 MEP1A / PPHA HEK293 过表达细胞裂解液 (阳性对照)

产品数据评论实验方法
表达宿主: Human Cells  
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10133-H08H-20
10133-H08H-10
20 µg 
10 µg 
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描述: Active  
表达宿主: Human Cells  
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50057-M08H-20
50057-M08H-10
20 µg 
10 µg 
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反应性: Human  
应用 : ELISA  
    10133-R017-50
    10133-R017-100
    50 µg 
    100 µg 
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    反应性: Human  
    应用 : ELISA  
      10133-R009-50
      10133-R009-100
      50 µg 
      100 µg 
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      反应性: Human  
      应用 : ELISA  
        10133-RP01-400
        10133-RP01-200
        10133-RP01-100
        400 µg 
        200 µg 
        100 µg 
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        反应性: Mouse  
        应用 : ELISA  IHC-P  
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        • Slide 1
        50057-R001-50
        50057-R001-100
        50 µg 
        100 µg 
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        反应性: Mouse  
        应用 : ELISA  WB  
        • Slide 1
        50057-RP01-400
        50057-RP01-200
        50057-RP01-100
        400 µg 
        200 µg 
        100 µg 
        Add to Cart
        反应性: Mouse  
        应用 : ELISA  WB  
        • Slide 1
        50057-RP02-50
        50057-RP02-200
        50057-RP02-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart

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        MEP1A lysate_category 研究背景

        Meprin A subunit alpha, also known as MEP1A, and Endopeptidase-2, is a single-pass type I  membrane protein which belongs to the peptidase M12A family. MEP1A contains one EGF-like domain, one MAM domain, and one MATH domain. Meprins are unique plasma membrane and secreted metalloproteinases that are highly regulated at the transcriptional and post-translational levels. Meprin alpha and beta subunits are abundantly expressed in kidney and intestinal epithelial cells, are secreted into the urinary tract and intestinal lumen, and are found in leukocytes and cancer cells under certain conditions. Meprins are capable of proteolytically degrading extracellular matrix proteins, proteolytically processing bioactive proteins, and play a role in inflammatory processes. Meprin A and B are highly regulated, secreted and cell-surface homo- and hetero-oligomeric enzymes. Meprins are abundantly expressed in kidney and intestine. The multidomain alpha and beta subunits have high sequence identity. They have very different substrate specificities, oligomerization potentials and are differentially regulated. Meprin A appears to be an important therapeutic target and urinary excretion appears to be a potential biomarker of acute kidney injury ( AKI ).

         MEP1A lysate_category 参考资料
      • Bertenshaw,GP. et al., 2002, Biol Chem. 383 (7-8):1175-83.
      • Bond, JS. et al., 2005, FEBS Lett. 579 (15): 3317-22.
      • Herzog, C. et al., 2007, Kidney Int. 71 (10): 1009-18.
      • Yura, RE. et al., 2009, Am J Physiol Renal Physiol. 296 (1): F135-44.
      • 请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”