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小鼠 IL10/IL-10/Interleukin-10 基因ORF全长cDNA克隆(表达载体), C-His 标签

产品数据评论实验方法
表达宿主: Human Cells  
  • Slide 1
10947-H07H-5
10947-H07H-20
10947-H07H-100
5 µg 
20 µg 
100 µg 
Add to Cart
表达宿主: E. coli  
  • Slide 1
10947-HNAE-500
10947-HNAE-5
10947-HNAE-20
10947-HNAE-100
10947-HNAE-1
500 µg 
5 µg 
20 µg 
100 µg 
1 mg 
Add to Cart
表达宿主: E. coli  
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80082-RNAE-20
80082-RNAE-10
20 µg 
10 µg 
Add to Cart
表达宿主: E. coli  
  • Slide 1
62000-WNAE-5
62000-WNAE-20
62000-WNAE-100
5 µg 
20 µg 
100 µg 
Add to Cart
反应性: Human  
应用 : ELISA  
    10947-RP01-400
    10947-RP01-200
    10947-RP01-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart
    反应性: Human  
    应用 : ELISA  
      10947-R001-50
      10947-R001-100
      50 µg 
      100 µg 
      Add to Cart
      反应性: Human  
      应用 : ELISA  
        10947-T16-50
        10947-T16-200
        10947-T16-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        反应性: Human  
        应用 : ELISA  
          10947-MM07-50
          10947-MM07-200
          10947-MM07-100
          50 µg 
          200 µg 
          100 µg 
          Add to Cart
          反应性: Human  
          应用 : ELISA  
            10947-R128-50
            10947-R128-100
            50 µg 
            100 µg 
            Add to Cart
            反应性: Human  
            应用 : 
              10947-MM03-50
              10947-MM03-200
              10947-MM03-100
              10947-MM03-1
              50 µg 
              200 µg 
              100 µg 
              1 mg 
              Add to Cart
              反应性: Mouse  
              应用 : WB  
              • Slide 1
              100319-T32-50
              100319-T32-200
              100319-T32-100
              50 µg 
              200 µg 
              100 µg 
              Add to Cart
              反应性: Feline  
              应用 : ELISA  
                67001-T16-50
                67001-T16-200
                67001-T16-100
                50 µg 
                200 µg 
                100 µg 
                Add to Cart
                反应性: Sus scrofa (Pig)  
                应用 : ELISA  WB  
                • Slide 1
                62000-T48-50
                62000-T48-200
                62000-T48-100
                50 µg 
                200 µg 
                100 µg 
                Add to Cart

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                IL10/IL-10/Interleukin-10 cdna-clone 研究背景

                IL-10 is a anti-inflammatory cytokine which belongs to the IL-10 family. It is produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types, while it is produced primarily by monocytes and to a lesser extent by lymphocytes. IL-10 is mainly expressed in monocytes and Type 2 T helper cells (TH2), mast cells, CD4+CD25+Foxp3+ regulatory T cells, and also in a certain subset of activated T cells and B cells. IL-10 has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. The importance of interleukin 10 for counteracting excessive immunity in the human body is revealed by the fact that patients with Crohn's disease react favorably towards treatment with bacteria producing recombinant IL-10. IL-10 inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen presenting cells. However, it is also stimulatory towards certain T cells and mast cells and stimulates B cell maturation and antibody production.

                Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

                小鼠 IL10/IL-10/Interleukin-10 cdna-clone 参考资料
              • Arimoto T, et al. (2007) Interleukin-10 protects against inflammation-mediated degeneration of dopaminergic neurons in substantia nigra. Neurobiol Aging. 28(6):894-906.
              • Han X, et al. (2010) Effect of cobalt protoporphyrin on hyperexpression of heme oxygenase-1 and secretion of IL-10 in rat bone marrow mesenchymal stem cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 18(5):1297-301.
              • Cui QQ, et al. (2011) Expression of RhoA in the lung tissue of acute lung injury rats and the influence of RhoA on the expression of IL-8 and IL-10. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 77(7): 1436-41.
              • 请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”