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小鼠 IGFBP4 基因ORF全长cDNA克隆(表达载体), C-His 标签

产品数据评论实验方法
描述: Active  
表达宿主: Human Cells  
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10967-H08H-5
10967-H08H-20
10967-H08H-100
5 µg 
20 µg 
100 µg 
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描述: Active  
表达宿主: Human Cells  
  • Slide 1
50250-M08H-5
50250-M08H-20
50250-M08H-100
5 µg 
20 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
90080-C08H-5
90080-C08H-20
90080-C08H-100
5 µg 
20 µg 
100 µg 
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反应性: Human  
应用 : ELISA  
    10967-MM02-50
    10967-MM02-200
    10967-MM02-100
    50 µg 
    200 µg 
    100 µg 
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    反应性: Mouse  
    应用 : ELISA  
      50250-RP02-50
      50250-RP02-200
      50250-RP02-100
      50 µg 
      200 µg 
      100 µg 
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      反应性: Cynomolgus  
      应用 : ELISA  IHC-P  
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      90080-T24-50
      90080-T24-200
      90080-T24-100
      50 µg 
      200 µg 
      100 µg 
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      反应性: Cynomolgus  
      应用 : ELISA  
        90080-MM01-50
        90080-MM01-200
        90080-MM01-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart

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        IGFBP4 cdna-clone 研究背景

        Insulin-like growth factor binding protein 4 (IGFBP-4) is a 24-kDa protein that binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. The Insulin-like growth factor-binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1. IGFBPs are clearly distinct but are sharing regions with strong homology. All members of the IGFBP family bind IGF-I and IGF-II with about equal affinity. Insulin-like growth factor (IGF) binding proteins (IGFBPs) have been shown to either inhibit or enhance the action of IGF, or act in an IGF-independent manner in the prostate. IGF-binding protein-4 (IGFBP-4) inhibits IGF-I action in vitro and is the most abundant IGFBP in the rodent arterial wall. Expression of IGFBP-4 mRNA in nontransgenic littermates was maximal in liver and kidney. IGFBP-4 is a functional antagonist of IGF-I action on SMC. There is mounting evidence that the structure of the IGFBP proteins plays a key role in the regulation of IGF bioavailability, by modulating its molecular size, capillary membrane permeability, target tissue specificity, cell membrane adherence and IGF affinity.

        小鼠 IGFBP4 cdna-clone 参考资料
      • Wang J, et al. (1998) Overexpression of insulin-like growth factor-binding protein-4 (IGFBP-4) in smooth muscle cells of transgenic mice through a smooth muscle alpha-actin-IGFBP-4 fusion gene induces smooth muscle hypoplasia. Endocrinology. 139(5): 2605-14.
      • Chernausek SD, et al. (1995) Proteolytic cleavage of insulin-like growth factor binding protein 4 (IGFBP-4). Localization of cleavage site to non-homologous region of native IGFBP-4. J Biol Chem. 1995 May 12;270(19):11377-82.
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