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小鼠 KLK-6 基因全长ORF克隆 (表达载体), C端His标签

产品数据评论实验方法
表达宿主: Human Cells  
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  • Slide 1
12142-HCCH-20
12142-HCCH-10
20 µg 
10 µg 
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描述: Active  
表达宿主: Human Cells  
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12142-H08H-10
12142-H08H-20
10 µg 
20 µg 
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反应性: Mouse  
应用 : ELISA  
    50255-RP01-200
    50255-RP01-100
    50255-RP01-400
    200 µg 
    100 µg 
     
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    反应性: Mouse  
    应用 : ELISA  WB  
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    50255-T48-100
    50255-T48-50
    100 µg 
    50 µg 
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    KLK6/Kallikrein 6/Neurosin cdna-clone 研究背景

    KLK6 (kallikrein-related peptidase 6), also known as Klk7, belongs to the peptidase S1 family, Kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK6 is a serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Klk7 shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. KLK6 degrades alpha-synuclein and prevents its polymerization, indicating that KLK6 may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. Klk7 may be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.

    Mouse KLK6/Kallikrein 6/Neurosin cdna-clone 参考资料
  • Krenzer S, et al. (2011) Expression and function of the kallikrein-related peptidase 6 in the human melanoma microenvironment. J Invest Dermatol. 131(11):2281-8.
  • Nathalie HV, et al. (2009) High kallikrein-related peptidase 6 in non-small cell lung cancer cells: an indicator of tumour proliferation and poor prognosis. J Cell Mol Med. 13(9B):4014-22.
  • Kim JT, et al. (2011) Up-regulation and clinical significance of serine protease kallikrein 6 in colon cancer. Cancer. 117(12):2608-19.
  • Scarisbrick IA, et al. (2011) Functional role of kallikrein 6 in regulating immune cell survival. PLoS One. 6(3):e18376.
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