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Endoglin / CD105 / ENG 抗体, 兔多抗

产品数据评论实验方法
描述: Active  
表达宿主: Human Cells  
  • Slide 1
10149-H02H-50
10149-H02H-20
50 µg 
20 µg 
Add to Cart
表达宿主: Human Cells  
  • Slide 1
10149-H08H-50
10149-H08H-20
50 µg 
20 µg 
Add to Cart
描述: Active  
表达宿主: Human Cells  
  • Slide 1
50407-M08H-50
50407-M08H-20
50407-M08H-100
50 µg 
20 µg 
100 µg 
Add to Cart

Endoglin/CD105  ELISA配对抗体

检测限: 31.25 pg/ml
SEK10149-5
SEK10149-15
5 Plates 
15 Plates 
Add to Cart
检测限: 31.25 pg/ml
SEK50407-5
SEK50407-15
5 Plates 
15 Plates 
Add to Cart

Endoglin/CD105  抗体Related Products

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Endoglin/CD105  antibody 研究背景

Endoglin, also known as CD105, is a type I  homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type I I receptor (TβRII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types.

 Endoglin/CD105  antibody 参考资料
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