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大鼠 PD1/PDCD1/CD279 基因ORF全长cDNA克隆(表达载体)

产品数据评论实验方法
描述: Active  
表达宿主: Human Cells  
  • Slide 1
10377-H03H-50
10377-H03H-100
50 µg 
100 µg 
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描述: Active  
表达宿主: Human Cells  
  • Slide 1
10377-H08H-50
10377-H08H-100
50 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
50124-M08H-200
50124-M08H-100
200 µg 
100 µg 
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描述: Active  
表达宿主: Human Cells  
  • Slide 1
50124-M03H-200
50124-M03H-100
200 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
80448-R02H-200
80448-R02H-100
200 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
80448-R08H-200
80448-R08H-100
200 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
90311-C02H-50
90311-C02H-100
50 µg 
100 µg 
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描述:   
表达宿主: Human Cells  
  • Slide 1
70109-D02H-200
70109-D02H-100
200 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
70109-D08H-200
70109-D08H-100
200 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
90305-K08H-50
90305-K08H-100
50 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
90305-K02H-50
90305-K02H-100
50 µg 
100 µg 
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反应性: Human  
应用 : ELISA  WB  
  • Slide 1
10377-T48-50
10377-T48-200
10377-T48-100
50 µg 
200 µg 
100 µg 
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反应性: Human  
应用 : 
  • Slide 1
  • Slide 1
  • Slide 1
10377-HN94-500
10377-HN94-200
500 µg 
200 µg 
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反应性: Human  
应用 : ELISA  
    10377-MF05-50
    10377-MF05-100
    50 µg 
    100 µg 
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    反应性: Human  
    应用 : ELISA  
      10377-RP03-400
      10377-RP03-200
      10377-RP03-100
      400 µg 
      200 µg 
      100 µg 
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      反应性: Human  
      应用 : 
        10377-MM03-50
        10377-MM03-200
        10377-MM03-100
        50 µg 
        200 µg 
        100 µg 
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        反应性: Human  
        应用 : ELISA  
          10377-R002-50
          10377-R002-100
          50 µg 
          100 µg 
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          反应性: Human  
          应用 : ELISA  IHC-P  
          • Slide 1
          • Slide 1
          • Slide 1
          10377-RD67-50
          10377-RD67-100
          50 µg 
          100 µg 
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          反应性: Human  
          应用 : B/N  
            10377-mhT28-500
            10377-mhT28-200
            500 µg 
            200 µg 
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            反应性: Human  
            应用 : ELISA  
              10377-RP04-50
              10377-RP04-200
              10377-RP04-100
              50 µg 
              200 µg 
              100 µg 
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              反应性: Human  
              应用 : B/N  
              • Slide 1
              10377-HF06-500
              10377-HF06-200
              500 µg 
              200 µg 
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              反应性: Human  
              应用 : ELISA  
                10377-MM07-50
                10377-MM07-200
                10377-MM07-100
                10377-MM07-1
                50 µg 
                200 µg 
                100 µg 
                1 mg 
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                反应性: Human  
                应用 : ELISA  IHC-P  
                • Slide 1
                • Slide 1
                • Slide 1
                10377-MF07-50
                10377-MF07-200
                10377-MF07-100
                50 µg 
                200 µg 
                100 µg 
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                反应性: Mouse  
                应用 : ELISA  
                  50124-R010-50
                  50124-R010-100
                  50 µg 
                  100 µg 
                  Add to Cart
                  反应性: Mouse  
                  应用 : ELISA  
                    50124-T16-50
                    50124-T16-100
                    50 µg 
                    100 µg 
                    Add to Cart
                    反应性: Mouse  
                    应用 : ELISA  IHC-P  
                    • Slide 1
                    50124-RP02-50
                    50124-RP02-100
                    50 µg 
                    100 µg 
                    Add to Cart
                    反应性: Mouse  
                    应用 : ELISA  
                      50124-RP01-400
                      50124-RP01-200
                      50124-RP01-100
                      400 µg 
                      200 µg 
                      100 µg 
                      Add to Cart
                      反应性: Canine  
                      应用 : ELISA  
                        70109-R039-50
                        70109-R039-100
                        50 µg 
                        100 µg 
                        Add to Cart
                        反应性: Canine  
                        应用 : ELISA  
                          70109-RP01-400
                          70109-RP01-200
                          70109-RP01-100
                          400 µg 
                          200 µg 
                          100 µg 
                          Add to Cart
                          反应性: Canine  
                          应用 : ELISA  
                            70109-T16-50
                            70109-T16-200
                            70109-T16-100
                            50 µg 
                            200 µg 
                            100 µg 
                            Add to Cart

                            PD1/PDCD1/CD279 cDNARelated Products

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                            PD1/PDCD1/CD279 cdna-clone 研究背景

                            Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. Furthermore, PD1 is shown to be a regulator of virus-specific CD8+ T cell survival in HIV infection. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.

                            Immune Checkpoint
                            Immune Checkpoint Blockade: Blocking Antibodies   Immune Checkpoint Blockade: PD1 / PDCD1 / CD279 Blocking Antibodies
                            Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IHC Antibodies   Immune Checkpoint Detection: WB Antibodies
                            Immune Checkpoint Proteins   PD1 / PDCD1 / CD279 Immune Checkpoint Proteins
                            PD1 / PDCD1 / CD279 Immune Checkpoint   PD1 / PDCD1 / CD279 Immune Checkpoint Antibodies
                            Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

                            Immunotherapy   Cancer Immunotherapy   Targeted Therapy

                            大鼠 PD1/PDCD1/CD279 cdna-clone 参考资料
                          • James ES, et al. (2005) PDCD1: a tissue-specific susceptibility locus for inherited inflammatory disorders. Genes Immun. 6(5): 430-7.
                          • Okazaki T, et al. (2007) PD-1 and PD-1 ligands: from discovery to clinical application. Int Immunol. 19(7): 813-24.
                          • del Rio ML, et al. (2008) PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation. Transpl Int. 21(11): 1015-28.
                          • Riley JL.(2009) PD-1 signaling in primary T cells. Immunol Rev. 229(1): 114-25.
                          • 请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”