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人 CXCL10 / Crg-2 基因ORF全长cDNA克隆(表达载体), N-Flag 标签

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表达宿主: E. coli  
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10768-HNAE-50
10768-HNAE-100
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反应性: Human  
应用 : ELISA  
    10768-RP01-400
    10768-RP01-200
    10768-RP01-100
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    反应性: Human  
    应用 : ELISA  
      10768-T16-50
      10768-T16-200
      10768-T16-100
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      反应性: Human  
      应用 : 
        10768-R121-50
        10768-R121-100
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        CXCL10 / Crg-2 cdna-clone 研究背景

        CXCL10, also known as crg-2, is a chemokine of the CXC subfamily and ligand for the receptor CXCR3. CXC chemokines are particularly significant for leukocyte infiltration in inflammatory diseases. CXCL10 has a three-dimensional crystal structure. Its signaling is mediated by the g protein-coupled receptor CXCR3, which is expressed on activated T cells and plays an important role in directing the migration of T cells, especially during Th1 responses. Binding of CXCL10 to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. It is chemotactic for monocytes and T-lymphocytes. CXCL10 can be secreted by several cell types in response to IFN-γ. Baseline pre-treatment plasma levels of CXCL10 are elevated in patients chronically infected with hepatitis C virus (HCV) of genotypes 1 or 4 who do not achieve a sustained viral response (SVR) after completion of antiviral therapy.

        Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

         CXCL10 / Crg-2 cdna-clone 参考资料
      • O'Donovan N, et al. (1999) Physical mapping of the CXC chemokine locus on human chromosome 4. Cytogenet. Cell Genet. 84(1-2):39-42.
      • Swaminathan GJ, et al. (2003) Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine. Structure. 11(5):521-32.
      • Booth V, et al. (2002) The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions. Biochemistry. 41(33):10418-25.
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