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大鼠 HVEM/TNFRSF14/CD270 基因ORF全长cDNA克隆(表达载体)

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描述:   
表达宿主: Human Cells  
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10334-H08H-200
10334-H08H-100
200 µg 
100 µg 
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描述: Active  
表达宿主: Human Cells  
  • Slide 1
10334-H03H-200
10334-H03H-100
200 µg 
100 µg 
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描述: Active  
表达宿主: Human Cells  
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10567-M03H-200
10567-M03H-100
200 µg 
100 µg 
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描述: Active  
表达宿主: CHO Stable Cells  
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10567-M03S-200
10567-M03S-100
200 µg 
100 µg 
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表达宿主: Human Cells  
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90109-C02H-50
90109-C02H-100
50 µg 
100 µg 
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反应性: Human  
应用 : 
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10334-MM11-P-25
10334-MM11-P-100
25 Test 
100 Tests 
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反应性: Human  
应用 : 
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10334-R004-P-25
10334-R004-P-100
25 Test 
100 Tests 
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反应性: Human  
应用 : 
  • Slide 1
10334-R004-F-25
10334-R004-F-100
25 Test 
100 Tests 
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反应性: Human  
应用 : 
  • Slide 1
10334-R004-A-25
10334-R004-A-100
25 Test 
100 Tests 
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反应性: Human  
应用 : 
  • Slide 1
10334-MM11-A-25
10334-MM11-A-100
25 Test 
100 Tests 
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反应性: Human  
应用 : 
    10334-R028-50
    10334-R028-100
    50 µg 
    100 µg 
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    反应性: Human  
    应用 : 
    • Slide 1
    10334-R004-50
    10334-R004-100
    50 µg 
    100 µg 
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    反应性: Human  
    应用 : ELISA  
      10334-RP01-400
      10334-RP01-200
      10334-RP01-100
      400 µg 
      200 µg 
      100 µg 
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      反应性: Human  
      应用 : 
      • Slide 1
      10334-MM11-50
      10334-MM11-200
      10334-MM11-100
      50 µg 
      200 µg 
      100 µg 
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      反应性: Human  
      应用 : ELISA  
        10334-T16-50
        10334-T16-200
        10334-T16-100
        50 µg 
        200 µg 
        100 µg 
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        HVEM/TNFRSF14/CD270 cDNARelated Products

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        HVEM/TNFRSF14/CD270 cdna-clone 研究背景

        Herpesvirus entry mediator (HVEM), also referred to as TNFRSF14, TR2 (TNF receptor-like molecule) and ATAR (another TRAF-associated receptor), is a member of type I transmembrane protein belonging to the TNF-receptor superfamily. It is expressed on many immune cells, including T and B cells, NK cells, monocytes, and neutrophils. Two TNF superfamily ligands lymphotoxin α (TNF-β) and LIGHT (TNFSF14) are identified as cellular ligands for HVEM and initiate the positive signaling. However, recent studies have revealed that HVEM is also involved in the unique inhibitory signaling pathway for T cells through activating tyrosine phosphorylation of the immunoreceptor tyrosine-based inhibitory motif (ITIM) in B and T lymphocyte attenuator (BTLA). HVEM provides a stimulatory signal following engagement with LIGHT (TNFSF14) on T cells. In contrast, it can also provide an inhibitory signal to T cells when it binds the B and T lymphocyte attenuator (BTLA), a ligand member of the Immunoglobulin (Ig) superfamily. Thus, HVEM may be viewed as a molecular switch, capable of facilitating both stimulatory and inhibitory cosignaling in T cells. Substantial evidence from both human disease and from experimental mouse models has indicated that dysregulation of the LIGHT-HVEM-BTLA cosignaling pathway can cause inflammation in the lung and in mucosal tissues.

        Immune Checkpoint
        Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies
        Immune Checkpoint Proteins
        Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

        Immunotherapy   Cancer Immunotherapy   Targeted Therapy

        大鼠 HVEM/TNFRSF14/CD270 cdna-clone 参考资料
      • Murphy KM, et al. (2006) Balancing co-stimulation and inhibition with BTLA and HVEM. Nat Rev Immunol. 6(9): 671-81.
      • Heo SK, et al. (2007) HVEM signaling in monocytes is mediated by intracellular calcium mobilization. J Immunol. 179(9): 6305-10.
      • Steinberg MW, et al. (2008) A crucial role for HVEM and BTLA in preventing intestinal inflammation. J Exp Med. 205(6): 1463-76.
      • Pasero C, et al. (2009) A role for HVEM, but not lymphotoxin-beta receptor, in LIGHT-induced tumor cell death and chemokine production. Eur J Immunol. 39(9): 2502-14.
      • Cheung TC. Modulation of T cell proliferation through the LIGHT-HVEM-BTLA cosignaling pathway. Recent Pat DNA Gene Seq. 3(3): 177-82.
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