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大鼠 IL-22R / IL22RA1 基因ORF全长cDNA克隆(表达载体)

产品数据评论实验方法
表达宿主: Human Cells  
  • Slide 1
80453-R08H-50
80453-R08H-200
50 µg 
200 µg 
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表达宿主: Human Cells  
  • Slide 1
80453-R02H-50
80453-R02H-200
50 µg 
200 µg 
Add to Cart
表达宿主: Human Cells  
  • Slide 1
70083-D02H-50
70083-D02H-100
50 µg 
100 µg 
Add to Cart
表达宿主: Human Cells  
  • Slide 1
70083-D08H-50
70083-D08H-100
50 µg 
100 µg 
Add to Cart

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IL-22R / IL22RA1 cdna-clone 研究背景

IL-22R belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains and is expressed in colon, liver, lung, pancreas and kidney. IL-22R also can be expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Overexpression of IL-22R can be detected in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients. IL-22R is a component of the receptor for IL20, IL22 and IL24. The component of IL-22R formed by IL22RA1 and IL10RB enables IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. IL-22R mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.

大鼠 IL-22R / IL22RA1 cdna-clone 参考资料
  • Xie MH, et al. (2000) Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. J Biol Chem. 275(40):31335-9.
  • Xu W, et al. (2001) A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist. Proc Natl Acad Sci. 98(17):9511-6.
  • Wu PW, et al. (2008) IL-22R, IL-10R2, and IL-22BP binding sites are topologically juxtaposed on adjacent and overlapping surfaces of IL-22. J Mol Biol. 382(5):1168-83.
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