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人 Adiponectin/Acrp30/ADIPOQ 基因ORF全长cDNA克隆(表达载体), N-Flag 标签

产品数据评论实验方法
描述:   
表达宿主: Human Cells  
  • Slide 1
10772-H02H-50
10772-H02H-100
50 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
50636-M08H-50
50636-M08H-100
50 µg 
100 µg 
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反应性: Mouse  
应用 : ELISA  
    50636-RP02-50
    50636-RP02-200
    50636-RP02-100
    50 µg 
    200 µg 
    100 µg 
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    反应性: Mouse  
    应用 : ELISA  
      50636-RP01-400
      50636-RP01-200
      50636-RP01-100
      400 µg 
      200 µg 
      100 µg 
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      反应性: Mouse  
      应用 : ELISA  
        50636-R038-50
        50636-R038-100
        50 µg 
        100 µg 
        Add to Cart

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        Adiponectin/Acrp30/ADIPOQ cdna-clone 研究背景

        Adiponectin (ADIPOQ), or 30 kDa adipocyte complement-related protein (Acrp30) is a protein secreted by adipose tissue, which acts to reduce insulin resistance and atherogenic damage, but it also exerts actions in other tissues. Adiponectin mediates its actions in the periphery mainly via two receptors, AdipoR1 and AdipoR2. Adiponectin influences gonadotropin release, normal pregnancy, and assisted reproduction outcomes. Adiponectin, a beneficial adipokine, represents a major link between obesity and reproduction. Higher levels of adiponectin are associated with improved menstrual function and better outcomes in assisted reproductive cycles. Unlike other adipocytokines produced by adipose tissue, adiponectin appears to have anti-inflammatory, anti-diabetic, and anti-atherogenic properties. Several clinical studies demonstrate the inverse relationship between plasma adiponectin levels and several inflammatory markers including C-reactive protein. Adiponectin attenuates inflammatory responses to multiple stimuli by modulating signaling pathways in a variety of cell types. The anti-inflammatory properties of adiponectin may be a major component of its beneficial effects on cardiovascular and metabolic disorders including atherosclerosis and insulin resistance. Additionally, it is important factor in chronic liver diseases and chronic kidney diseases. Some cancer cell types express adiponectin receptors. Thus Adiponectin may act on tumour cells directly by binding and activating adiponectin receptors and downstream signalling pathways.

         Adiponectin/Acrp30/ADIPOQ cdna-clone 参考资料
      • Cui J, et al. (2011) The role of adiponectin in metabolic and vascular disease: a review. Clin Nephrol. 75(1): 26-33.
      • Michalakis KG, et al. (2010) The role of adiponectin in reproduction: from polycystic ovary syndrome to assisted reproduction. Fertil Steril. 94(6): 1949-57.
      • Dez JJ, et al.. (2010) The role of the novel adipocyte-derived protein adiponectin in human disease: an update. Mini Rev Med Chem. 10(9): 856-69.
      • Ouchi N, et al. (2007) Adiponectin as an anti-inflammatory factor. Clin Chim Acta. 380(1-2): 24-30.
      • Barb D, et al. (2006) Adiponectin: a link between obesity and cancer. Expert Opin Investig Drugs. 15(8): 917-31.
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