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大鼠 PD-L2/B7-DC/CD273 基因ORF全长cDNA克隆(表达载体)

产品数据评论实验方法
表达宿主: Human Cells  
  • Slide 1
10292-H02H-200
10292-H02H-100
200 µg 
100 µg 
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描述: Active  
表达宿主: Human Cells  
  • Slide 1
10292-H03H-200
10292-H03H-100
200 µg 
100 µg 
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描述: Active  
表达宿主: Human Cells  
  • Slide 1
10292-H08H-200
10292-H08H-100
200 µg 
100 µg 
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描述: Active  
表达宿主: Human Cells  
  • Slide 1
50804-M08H-200
50804-M08H-100
200 µg 
100 µg 
Add to Cart
描述: Active  
表达宿主: Human Cells  
  • Slide 1
50804-M02H-200
50804-M02H-100
200 µg 
100 µg 
Add to Cart
表达宿主: Human Cells  
  • Slide 1
80454-R02H-200
80454-R02H-100
200 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
80454-R08H-200
80454-R08H-100
200 µg 
100 µg 
Add to Cart
表达宿主: Human Cells  
  • Slide 1
90249-C02H-200
90249-C02H-100
200 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
90249-C08H-200
90249-C08H-100
200 µg 
100 µg 
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反应性: Human  
应用 : FCM  
  • Slide 1
10292-R002-F-25
10292-R002-F-100
25 Test 
100 Tests 
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反应性: Human  
应用 : ELISA  WB  
  • Slide 1
10292-R018-50
10292-R018-100
50 µg 
100 µg 
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反应性: Human  
应用 : FCM  
  • Slide 1
10292-R002-50
10292-R002-100
50 µg 
100 µg 
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反应性: Human  
应用 : 
    10292-M324-50
    10292-M324-200
    10292-M324-100
    10292-M324-1
    50 µg 
    200 µg 
    100 µg 
    1 mg 
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    反应性: Human  
    应用 : ELISA  
      10292-RP01-200
      10292-RP01-100
      200 µg 
      100 µg 
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      反应性: Human  
      应用 : ELISA  
        10292-RP02-50
        10292-RP02-200
        10292-RP02-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        反应性: Mouse  
        应用 : ELISA  
          50804-RP01-400
          50804-RP01-200
          50804-RP01-100
          400 µg 
          200 µg 
          100 µg 
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          反应性: Mouse  
          应用 : ELISA  
            50804-T16-50
            50804-T16-200
            50804-T16-100
            50 µg 
            200 µg 
            100 µg 
            Add to Cart

            PD-L2/B7-DC/CD273 cDNARelated Products

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            PD-L2/B7-DC/CD273 cdna-clone 研究背景

            Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B cells, INF-γ in monocytes, or LPS plus IFN-γ in dendritic cells. The CD28 and B7 protein families are critical regulators of immune responses. PD-L2 and PD-L1 are two ligands for PD-1, member of the CD28/CTLA4 family expressed on activated lymphoid cells, and thus provide signals for regulating T cell activation and immune tolerance. The interaction of B7-DC/PD-1 exhibited a 2-6-fold higher affinity compared with the interaction of B7-H1/PD-1.

            Immune Checkpoint
            Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
            Immune Checkpoint Proteins
            Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

            Immunotherapy   Cancer Immunotherapy   Targeted Therapy

            大鼠 PD-L2/B7-DC/CD273 cdna-clone 参考资料
          • Latchman Y, et al. (2001) PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol. 2: 261-8.
          • Carreno BM, et al. (2005) Therapeutic opportunities in the B7/CD28 family of ligands and receptors. Curr Opin Pharmacol. 5(4): 424-30.
          • Radhakrishnan S, et al. (2007) B7-DC/PD-L2 cross-linking induces NF-kappaB-dependent protection of dendritic cells from cell death. J Immunol. 178(3): 1426-32.
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