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人 ASGPR1 基因ORF全长cDNA克隆(表达载体), N-Flag 标签

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表达宿主: Human Cells  
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10773-H07H-50
10773-H07H-100
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表达宿主: Human Cells  
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50083-M07H-50
50083-M07H-100
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反应性: Human  
应用 : ELISA  
    10773-R023-50
    10773-R023-100
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    反应性: Human  
    应用 : IHC-P  
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    10773-R011-50
    10773-R011-100
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    反应性: Human  
    应用 : ELISA  WB  IHC-P  IP  
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    10773-RP02-50
    10773-RP02-200
    10773-RP02-100
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    反应性: Human  
    应用 : 
      10773-R024-50
      10773-R024-100
      10773-R024-1
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      100 µg 
      1 mg 
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      反应性: Human  
      应用 : ELISA  
        10773-RP01-400
        10773-RP01-200
        10773-RP01-100
        400 µg 
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        反应性: Human  
        应用 : WB  IP  
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        10773-R021-50
        10773-R021-100
        10773-R021-1
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        100 µg 
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        反应性: Mouse  
        应用 : ELISA  WB  IHC-P  IP  
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        50083-RP02-50
        50083-RP02-200
        50083-RP02-100
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        200 µg 
        100 µg 
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        反应性: Mouse  
        应用 : ELISA  
          50083-R103-50
          50083-R103-100
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          100 µg 
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          反应性: Mouse  
          应用 : IHC-P  
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          50083-R114-50
          50083-R114-100
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          100 µg 
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          反应性: Mouse  
          应用 : ELISA  
            50083-RP01-400
            50083-RP01-200
            50083-RP01-100
            400 µg 
            200 µg 
            100 µg 
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            ASGPR1  cdna-clone 研究背景

            The asialoglycoprotein receptor (ASGPR), an endocytotic cell surface receptor expressed by hepatocytes, is triggered by triantennary binding to galactose residues of macromolecules such as asialoorosomucoid (ASOR). ASGPR belongs to the long-form subfamily of the C-type/Ca2+ dependent lectin family. It is a complex of two noncovalently-linked and highly homologous subunits, a major 42 kDa glycoprotein ASGPR1(MHL-1) and a minor 51 kDa glycoprotein ASGR2 (MHL-2). ASGPR1 is synthesized as a type II transmembrane protein that contains a cytosolic N-terminal domain, a single transmembrane segment, and an extracellular domain which contains two important structural regions. The first is a stalk domain that contributes to noncovalent oligomerization, and the second is a Ca2+-dependent carbohydrate binding domain at the very C-terminus that is unusually stabilized by three ions. The research regarded that ASGPR1 could be targeted for anti- hepatitis B virus (HBV) drug development.

             ASGPR1  cdna-clone 参考资料
          • Yang J, et al. (2006) Antisense oligonucleotides targeted against asialoglycoprotein receptor 1 block human hepatitis B virus replication. J Viral Hepat. 13(3): 158-65.
          • Li Y, et al. (2008) Targeted delivery of macromolecular drugs: asialoglycoprotein receptor (ASGPR) expression by selected hepatoma cell lines used in antiviral drug development. Curr Drug Deliv. 5(4): 299-302.
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