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大鼠 IL-17F 基因ORF全长cDNA克隆(表达载体)

产品数据评论实验方法
描述: Active  
表达宿主: Human Cells  
  • Slide 1
11855-H07H-5
11855-H07H-20
11855-H07H-100
5 µg 
20 µg 
100 µg 
Add to Cart
表达宿主: E. coli  
  • Slide 1
11855-HNAE-5
11855-HNAE-20
11855-HNAE-100
5 µg 
20 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
51097-M08H-50
51097-M08H-20
50 µg 
20 µg 
Add to Cart
表达宿主: E. coli  
  • Slide 1
51097-MNAE-50
51097-MNAE-20
50 µg 
20 µg 
Add to Cart
表达宿主: Baculovirus-Insect Cells  
  • Slide 1
80462-R08B-50
80462-R08B-20
50 µg 
20 µg 
Add to Cart
反应性: Human  
应用 : ELISA  WB  IP  
  • Slide 1
  • Slide 1
11855-T52-50
11855-T52-200
11855-T52-100
50 µg 
200 µg 
100 µg 
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反应性: Human  
应用 : 
    11855-R003-50
    11855-R003-100
    50 µg 
    100 µg 
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    反应性: Mouse  
    应用 : ELISA  
      51097-RP01-400
      51097-RP01-200
      51097-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart
      反应性: Mouse  
      应用 : ELISA  WB  
      • Slide 1
      51097-T48-50
      51097-T48-200
      51097-T48-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      反应性: Rat  
      应用 : ELISA  WB  
      • Slide 1
      80462-T48-50
      80462-T48-200
      80462-T48-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart

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      IL-17F cdna-clone 研究背景

      Interleukin-17F (IL-17F) is a cytokine that shares sequence similarity with IL17. The most notable role of IL-17 is it involvement in inducing and mediating proinflammatory responses. IL-17 is commonly associated with allergic responses. IL-17F is expressed by activated T cells, and was expressed only in activated CD4+ T cells and activated monocytes. IL-17F has been shown to stimulate the production of several other cytokines, including IL6 and IL8. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. Recombinant human IL-17F did not stimulate the proliferation of hematopoietic progenitors or the migration of mature leukocytes. However, it markedly inhibited the angiogenesis of human endothelial cells and induced endothelial cells to produce IL-2, TGF-{beta}, and monocyte chemoattractant protein-1. IL-17F stimulates the production of other cytokines and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. IL-17F stimulates PBMC and T-cell proliferation. It also function in inhibiting angiogenesis By similarity. IL-17F plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation.

      大鼠 IL-17F cdna-clone 参考资料
      et al..
    • Starnes T, et al.. (2001) Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production. J Immunol. 167(8): 4137-40.
    • Hymowitz SG, et al.. (2001) IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. EMBO J. 20(19): 5332-41.
    • McAllister F, et al.. (2005) Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis. J Immunol. 175(1): 404-12.
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