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人 IL-22BP/IL-22RA2 transcript variant 1 基因ORF全长cDNA克隆(表达载体), N-Flag 标签

产品数据评论实验方法
表达宿主: Human Cells  
  • Slide 1
11025-H08H-50
11025-H08H-20
50 µg 
20 µg 
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表达宿主: Human Cells  
  • Slide 1
11025-H03H-50
11025-H03H-20
50 µg 
20 µg 
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反应性: Human  
应用 : ELISA  
    11025-MM05-50
    11025-MM05-200
    11025-MM05-100
    50 µg 
    200 µg 
    100 µg 
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    反应性: Human  
    应用 : ELISA  
      11025-RP02-50
      11025-RP02-200
      11025-RP02-100
      50 µg 
      200 µg 
      100 µg 
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      反应性: Human  
      应用 : ELISA  
        11025-R028-50
        11025-R028-100
        50 µg 
        100 µg 
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        反应性: Human  
        应用 : ELISA  
          11025-RP01-400
          11025-RP01-200
          11025-RP01-100
          400 µg 
          200 µg 
          100 µg 
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          IL-22BP/IL-22RA2 cdna-clone 研究背景

          Interleukin-22 receptor subunit alpha-2 (IL-22RA2), also known as interleukin-22-binding protein (IL-22BP), is a subunit of the receptor for interleukin 22. IL-22BP belongs to the type I I cytokine receptor family and contains 3 fibronectin type-III domains. IL-22BP/IL-22RA2 is expressed in a range of tissues, including those in the digestive, female reproductive, and immune systems. It is expressed in placenta, spleen, breast, skin and lung. It is also detected in intestinal tract, testis, brain, heart and thymus. The dominant cell types expressing IL-22BP/IL-22RA2 were mononuclear cells and epithelium. IL-22BP/IL-22RA2 may play an important role as an IL-22 antagonist in the regulation of inflammatory responses. Interleukin-22 (IL-22) is a member of IL-10 family. It is produced by T cells and induces the production of acute-phase reactants. IL-22 plays important roles in immune response through activation of the STAT 3 signal transduction pathway. Two types of IL-22-binding receptor have been discovered, a membrane-bound receptor and a soluble receptor.

           IL-22BP/IL-22RA2 cdna-clone 参考资料
        • Whittington HA, et al. (2004) Interleukin-22: a potential immunomodulatory molecule in the lung. Am J Respir Cell Mol Biol. 31(2): 220-6.
        • Dumoutier L, et al. (2001) Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22. J Immunol. 166(12): 7090-5.
        • Wei CC, et al. (2003) Cloning and characterization of mouse IL-22 binding protein. Genes Immun. 4(3): 204-11.
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