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大鼠 Fetuin-A 基因ORF全长cDNA克隆(表达载体)

产品数据评论实验方法
描述: Active  
表达宿主: Human Cells  
  • Slide 1
10318-H08H-50
10318-H08H-100
50 µg 
100 µg 
Add to Cart
描述: Active  
表达宿主: Human Cells  
  • Slide 1
50093-M08H-50
50093-M08H-100
50 µg 
100 µg 
Add to Cart
反应性: Human  
应用 : ELISA  
    10318-T16-50
    10318-T16-200
    10318-T16-100
    50 µg 
    200 µg 
    100 µg 
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    反应性: Human  
    应用 : ELISA  IF  ICC/IF  
    • Slide 1
    • Slide 1
    • Slide 1
    10318-R001-50
    10318-R001-100
    10318-R001-1
    50 µg 
    100 µg 
    1 mg 
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    反应性: Human  
    应用 : ELISA  
      10318-MM02-50
      10318-MM02-200
      10318-MM02-100
      10318-MM02-1
      50 µg 
      200 µg 
      100 µg 
      1 mg 
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      反应性: Human  
      应用 : ELISA  
        10318-RP01-400
        10318-RP01-200
        10318-RP01-100
        400 µg 
        200 µg 
        100 µg 
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        反应性: Mouse  
        应用 : ELISA  IHC-P  
        • Slide 1
        50093-RP02-50
        50093-RP02-200
        50093-RP02-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        反应性: Mouse  
        应用 : 
          50093-R012-50
          50093-R012-100
          50093-R012-1
          50 µg 
          100 µg 
          1 mg 
          Add to Cart
          反应性: Mouse  
          应用 : IHC-P  
          • Slide 1
          50093-R022-50
          50093-R022-100
          50 µg 
          100 µg 
          Add to Cart
          反应性: Mouse  
          应用 : ELISA  
            50093-RP01-400
            50093-RP01-200
            50093-RP01-100
            400 µg 
            200 µg 
            100 µg 
            Add to Cart
            反应性: Mouse  
            应用 : ELISA  
              50093-R002-50
              50093-R002-100
              50 µg 
              100 µg 
              Add to Cart

              Fetuin-A ELISA配对抗体

              检测限: 12.5 pg/ml
              SEKA10318-5
              SEKA10318-15
              5 Plates 
              15 Plates 
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              检测限: 312.5 pg/ml
              SEK50093-5
              SEK50093-15
              5 Plates 
              15 Plates 
              Add to Cart

              Fetuin-A cDNARelated Products

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              Fetuin-A cdna-clone 研究背景

              Fetuin-A, also known as Alpha-2-HS-Glycoprotein (AHSG), belongs to the Fetuin family, is a plasma binding protein, and is more abundant in fetal than adult blood. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. Fetuins are carrier proteins like albumin. Fetuin-A forms soluble complexes with calcium and phosphate and thus is a carrier of otherwise insoluble calcium phosphate. Thus Fetuin-A is a potent inhibitor of pathological calcification. The circulating levels of fetuin-A, a well-described inhibitor of calcification, regulate the cell-dependent process of osteogenesis. The low circulating fetuin-A levels are associated with a greater prevalence and/or severity of Vascular calcification (VC) and increased risk for all-cause and cardiovascular mortality. However, high circulating fetuin-A levels appear to induce insulin resistance and, in non-dialyzed subjects with diabetic nephropathy, are directly related to VC burden. The emerging role of fetuin-A deficiency as a risk factor in dialysis patients was documented in cross-sectional studies demonstrating a significant correlation with all-cause and cardiovascular mortality. Additionally, Human fetuin-A is a negative acute phase protein involved in inflammatory diseases, thus being a potential physiological regulator of meprin activity. Fetuin-A is a broad-range protease inhibitor. Fetuin-A and cystatin C as endogenous proteolytic regulators of meprin activity broadens our understanding of the proteolytic network in plasma.

              大鼠 Fetuin-A cdna-clone 参考资料
            • Mehrotra R. (2007) Emerging role for fetuin-A as contributor to morbidity and mortality in chronic kidney disease. Kidney Int. 72(2): 137-40.
            • Westenfeld R, et al. (2007) Vascular calcification and fetuin-A deficiency in chronic kidney disease. Trends Cardiovasc Med. 17(4): 124-8.
            • Heiss A, et al. (2008). Hierarchical role of fetuin-A and acidic serum proteins in the formation and stabilization of calcium phosphate particles. J Biol Chem. 283 (21): 14815-25.
            • Jahnen-Dechent W, et al. (2008). Mineral chaperones: a role for fetuin-A and osteopontin in the inhibition and regression of pathologic calcification. J Mol Med. 86 (4): 379-89.
            • Hedrich J, et al. (2010) Fetuin-A and cystatin C are endogenous inhibitors of human meprin metalloproteases. Biochemistry. 49(39): 8599-607.
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