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人 CD5L 基因ORF全长cDNA克隆(表达载体), N-Flag 标签

产品数据评论实验方法
表达宿主: Human Cells  
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10791-H08H-50
10791-H08H-100
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表达宿主: Human Cells  
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50020-M08H-50
50020-M08H-100
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反应性: Mouse  
应用 : ELISA  
    50020-RP01-400
    50020-RP01-200
    50020-RP01-100
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    反应性: Mouse  
    应用 : ELISA  
      50020-R257-50
      50020-R257-100
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      反应性: Mouse  
      应用 : ELISA  
        50020-R203-50
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        反应性: Mouse  
        应用 : ELISA  IHC-P  
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        50020-T24-50
        50020-T24-200
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        反应性: Mouse  
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          50020-R054-50
          50020-R054-100
          50020-R054-1
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          反应性: Mouse  
          应用 : ELISA  
            50020-R038-50
            50020-R038-100
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            反应性: Mouse  
            应用 : ELISA  
              50020-RP02-50
              50020-RP02-200
              50020-RP02-100
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              CD5L cdna-clone 研究背景

              CD5L, also known as CD5 antigen-like, is a soluble protein belonging to group B of the scavenger receptor cysteine-rich (SRCR) superfamily and contains three SRCR domains. It is a secreted glycoprotein and expressed by macrophages presentin lymphoid tissues (spleen, lymph node, thymus, and bone marrow). It binds to myelomonocytic and lymphoid cells and may play an important role in the regulation of the innate and adaptive immune systems. CD5L functions as a pattern recognition molecule by binding both lipoteichoic acid (LTA) on Gram positive and lipopolysaccharide (LPS) on Gram negative bacteria. and the SRCR domain 1 of CD5L retains both the LPS and LTA binding activities. In addtion, it is revealed that CD5L seems to play a role as an inhibitor of apoptosis.

               CD5L cdna-clone 参考资料
            • Resnick, D. et al., 1994, Trends Biochem. Sci. 19: 5-8.
            • Gebe, J. A. et al., 1997, J. Biol. Chem. 272 (10): 6151–6158.
            • Sarrias, M.R. et al., 2004, Crit. Rev. Immunol. 24: 1-37.
            • Mukhopadhyay, S. and Gordon, S., 2004, Immunobiology 209: 39-49.
            • Sarrias, M. R. et al.,2005, J. Biol. Chem. 280 (42): 35391–35398.
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