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大鼠 SerpinA1 基因ORF全长cDNA克隆(表达载体)

产品数据评论实验方法
描述: Active  
表达宿主: Human Cells  
  • Slide 1
10306-H08H-20
10306-H08H-10
20 µg 
10 µg 
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表达宿主: Human Cells  
  • Slide 1
80476-R08H-50
80476-R08H-10
50 µg 
10 µg 
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反应性: Human  
应用 : ELISA  
    10306-RP02-50
    10306-RP02-200
    10306-RP02-100
    50 µg 
    200 µg 
    100 µg 
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    反应性: Human  
    应用 : 
      10306-R142-50
      10306-R142-100
      10306-R142-1
      50 µg 
      100 µg 
      1 mg 
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      反应性: Human  
      应用 : ELISA  WB  
      • Slide 1
      10306-RP01-400
      10306-RP01-200
      10306-RP01-100
      400 µg 
      200 µg 
      100 µg 
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      反应性: Human  
      应用 : 
        10306-R005-50
        10306-R005-100
        10306-R005-1
        50 µg 
        100 µg 
        1 mg 
        Add to Cart
        反应性: Human  
        应用 : ELISA  
          10306-R204-50
          10306-R204-100
          50 µg 
          100 µg 
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          反应性: Rat  
          应用 : ELISA  
            80476-RP01-400
            80476-RP01-200
            80476-RP01-100
            400 µg 
            200 µg 
            100 µg 
            Add to Cart
            反应性: Rat  
            应用 : 
              80476-R005-50
              80476-R005-100
              50 µg 
              100 µg 
              Add to Cart
              反应性: Rat  
              应用 : ELISA  
                80476-T16-50
                80476-T16-200
                80476-T16-100
                50 µg 
                200 µg 
                100 µg 
                Add to Cart

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                SerpinA1 cdna-clone 研究背景

                SerpinA1, also known as Alpha-1 antitrypsin (AAT), is a prototype member of the Serpin superfamily of the serine protease inhibitors. This serine protease inhibitor blocks the protease, neutrophil elastase. Alpha-1 antitrypsin is mainly produced in the liver and acts as an antiprotease. Its principal function is to inactivate neutrophil elastase, preventing tissue damage. SerpinA1 (alpha1-antitrypsin), an acute phase protein and the classical neutrophil elastase inhibitor, is localized within lipid rafts in primary human monocytes in vitro. It association with monocytes is inhibited by cholesterol depleting/efflux-stimulating agents (nystatin, filipin, MbetaCD (methyl-beta-cyclodextrin) and oxidized low-density lipoprotein (oxLDL) and conversely, enhanced by free cholesterol. Furthermore, SerpinA1/monocyte association per se depletes lipid raft cholesterol as characterized by the activation of extracellular signal-regulated kinase 2, formation of cytosolic lipid droplets, and a complete inhibition of oxLDL uptake by monocytes. Previous population studies have suggested that heterozygote status for the AAT gene (SerpinA1) is a risk factor for chronic rhinosinusitis with nasal polyposis (CRSwNP). Alpha-1 antitrypsin deficiency is a recently identified genetic disease that occurs almost as frequently as cystic fibrosis. It is caused by various mutations in the SerpinA1 gene, and has numerous clinical implications. Alpha-1 antitrypsin deficiency is an inherited disease affecting the lung and liver. In the liver, alpha-1 antitrypsin deficiency may manifest as benign neonatal hepatitis syndrome; a small percentage of adults develop liver fibrosis, with progression to cirrhosis and hepatocellular carcinoma. Its most important physiologic functions are the protection of pulmonary tissue from aggressive proteolytic enzymes and regulation of pulmonary immune processes.

                大鼠 SerpinA1 cdna-clone 参考资料
              • Khnlein T, et al. (2008) Alpha-1 antitrypsin deficiency: pathogenesis, clinical presentation, diagnosis, and treatment. Am J Med. 121(1): 3-9.
              • Camelier AA, et al. (2008) Alpha-1 antitrypsin deficiency: diagnosis and treatment. J Bras Pneumol. 34(7): 514-27.
              • Subramaniyam D, et al. (2010) Cholesterol rich lipid raft microdomains are gateway for acute phase protein, SERPINA1. Int J Biochem Cell Biol. 42(9): 1562-70.
              • Kilty SJ, et al. (2010) Polymorphisms in the SERPINA1 (Alpha-1-Antitrypsin) gene are associated with severe chronic rhinosinusitis unresponsive to medical therapy. Am J Rhinol Allergy. 24(1): e4-9.
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