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人 RCN3 基因ORF全长cDNA克隆(表达载体), C-Flag 标签

产品数据评论实验方法
表达宿主: Human Cells  
  • Slide 1
13533-H08H-20
13533-H08H-100
20 µg 
100 µg 
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表达宿主: Human Cells  
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51928-M08H-20
51928-M08H-100
20 µg 
100 µg 
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表达宿主: Human Cells  
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80877-R08H-20
80877-R08H-100
20 µg 
100 µg 
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RCN3 cDNARelated Products

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RCN3 cdna-clone 研究背景

RCN3 belongs to the CREC family which contains multiple EF-hand Ca2+-binding proteins localized to the secretory pathway. RCN3 sequence is characterized by the presence of five Arg-Xaa-Xaa-Arg motifs, which represents the target sequence of subtilisin-like proprotein convertases(SPCs). SPCs are a family of seven structurally related serine endoproteases that are involved in the proteolytic activation of proproteins.RCN3 is transiently associated with proPACE4, but not with mature PACE4. Inhibition of PACE4 maturation by a Ca2+ ionophore resulted in accumulation of the proPACE4-RCN-3 complex in cells. It has been proposed that elective and transient association of RCN3 with the precursor of PACE4 plays an important role in the biosynthesis of PACE4.

 RCN3 cdna-clone 参考资料
  • Danielsen JM, et al. (2011) Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Mol Cell Proteomics. 10(3):M110.003590.
  • Rual JF, et al. (2005) Towards a proteome-scale map of the human protein-protein interaction network. Nature. 437(7062):1173-8.
  • Kamatani Y, et al. (2010) Genome-wide association study of hematological and biochemical traits in a Japanese population. Nat Genet. 42(3):210-5.
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