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人 CXADR / CAR 基因ORF全长cDNA克隆(表达载体), N-Flag 标签

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表达宿主: Human Cells  
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表达宿主: Human Cells  
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10799-H08H-50
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表达宿主: Human Cells  
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表达宿主: Human Cells  
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反应性: Human  
应用 : FCM  
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10799-R271-F-25
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应用 : FCM  
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    反应性: Human  
    应用 : FCM  IF  ICC/IF  
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    反应性: Human  
    应用 : ELISA  
      10799-R068-50
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      反应性: Human  
      应用 : ELISA  
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        反应性: Human  
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          反应性: Human  
          应用 : ELISA  
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            反应性: Mouse  
            应用 : ELISA  IHC-P  
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            反应性: Mouse  
            应用 : ELISA  
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              反应性: Mouse  
              应用 : ELISA  IHC-P  
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              50019-R001-50
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              CXADR / CAR cdna-clone 研究背景

              CXADR (coxsackie virus and adenovirus receptor), also known as CAR, is a type I  transmembrane glycoprotein belonging to the CTX family of the Ig superfamily, and is essential for normal cardiac development in the mouse. Proposed as a homophilic cell adhesion molecule, CXADR is a component of the epithelial apical junction complex that is essential for the tight junction integrity, and probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN). Mature mouse CXADR structrually comprises a 218 aa extracellular domain (ECD) with a V-type (D1) and a C2-type (D2) Ig-like domain, a 21 aa transmembrane segment and a 107 aa intracellular domain, among which,D1 is thought to be responsible for homodimer formation in trans within tight junctions. The ECD of mouse CXADR shares 97%, 90% sequence identity with the corresponding regions of rat, human CXADR.

               CXADR / CAR cdna-clone 参考资料
            • Tomko, R.P. et al., 1997, Proc. Natl. Acad. Sci. U.S.A. 94 (7): 3352–3356.
            • van Raaij , M.J. et al., 2001, Structure. 8 (11): 1147–1155.
            • Cohen, C.J. et al., 2001, J. Biol. Chem. 276 (27): 25392–25398.
            • Carson, S.D. et al., 2002, Rev. Med. Virol. 11 (4): 219–226.
            • Selinka, H.C. et al., 2004, Med. Microbiol. Immunol. 193 (2-3): 127–131.
            • Philipson, L. et al., 2004, Curr. Top. Microbiol. Immunol. 273:87-111.
            • Raschperger, E. et al., 2006, Exp. Cell Res. 312: 1566-1580.
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