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大鼠 PEDF 基因ORF全长cDNA克隆(表达载体)

产品数据评论实验方法
表达宿主: Human Cells  
  • Slide 1
11104-H08H-50
11104-H08H-20
50 µg 
20 µg 
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表达宿主: Human Cells  
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50235-M08H-50
50235-M08H-20
50 µg 
20 µg 
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表达宿主: Human Cells  
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80481-R08H-5
80481-R08H-20
80481-R08H-100
5 µg 
20 µg 
100 µg 
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反应性: Human  
应用 : WB  
  • Slide 1
11104-R033-50
11104-R033-100
50 µg 
100 µg 
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反应性: Human  
应用 : ELISA  
    11104-RP01-400
    11104-RP01-200
    11104-RP01-100
    400 µg 
    200 µg 
    100 µg 
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    反应性: Human  
    应用 : ELISA  WB  IP  
    • Slide 1
    • Slide 1
    11104-RP02-50
    11104-RP02-200
    11104-RP02-100
    50 µg 
    200 µg 
    100 µg 
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    反应性: Human  
    应用 : ELISA  
      11104-R013-50
      11104-R013-100
      50 µg 
      100 µg 
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      反应性: Human  
      应用 : ELISA  
        11104-T16-50
        11104-T16-200
        11104-T16-100
        50 µg 
        200 µg 
        100 µg 
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        反应性: Rat  
        应用 : ELISA  
          80481-T16-50
          80481-T16-200
          80481-T16-100
          50 µg 
          200 µg 
          100 µg 
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          PEDF cdna-clone 研究背景

          Pigment epithelium-derived factor, also known as PEDF, Serpin F1, and SERPINF1, is a multiple functional protein which has both anti-angiogenic activity and neurotrophic activity at the same time. PEDF is a secreted glycoprotein that belongs to the noninhibitory serpin. It has an alpha/beta core serine-protease inhibitor domain, three major beta-sheets, and ten alpha-helices. PEDF does not inhibit either serine or cysteine proteinases. PEDF exerts diverse physiological activities including anti-angiogenesis, anti-vasopermeability, anti-tumor, and neurotrophic activities. PEDF acts via multiple high affinity ligands and cell receptors. It has been described as a natural angiogenesis inhibitor with neurotrophic and immune-modulation properties. PEDF induces macrophages apoptosis and necrosis through the activation of peroxisome proliferator-activated receptor-gamma by which PEDF could modulate inflammatory reactions in septic shock. It balances angiogenesis in the eye and blocks tumor progression.

          大鼠 PEDF cdna-clone 参考资料
        • Ren, JG. et al., 2005, Med Hypotheses. 64 (1): 74-8.
        • Filleur, S. et al., 2009. J Cell Biochem. 106 (5): 769-75.
        • Kawaguchi, T. et al., 2010, Curr Mol Med. 10 (3): 302-11.
        • Yamagishi, SI. et al., 2010, Curr Mol Med. 10 (3): 284-91.
        • Nakamura, T. et al., 2010, Curr Mol Med. 10 (3): 312-6.
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