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大鼠 SUMO1/SUMO-1 基因ORF全长cDNA克隆(表达载体)

产品数据评论实验方法
表达宿主: E. coli  
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13095-H07E-50
13095-H07E-20
50 µg 
20 µg 
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反应性: Human  
应用 : ELISA  
    13095-RP01-400
    13095-RP01-200
    13095-RP01-100
    400 µg 
    200 µg 
    100 µg 
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    反应性: Human  
    应用 : ELISA  
      13095-R003-50
      13095-R003-100
      50 µg 
      100 µg 
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      反应性: Human  
      应用 : ELISA  WB  IP  
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      13095-RP02-50
      13095-RP02-200
      13095-RP02-100
      50 µg 
      200 µg 
      100 µg 
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      SUMO1/SUMO-1 cdna-clone 研究背景

      Small ubiquitin-like modifier protein (SUMO) modification is a highly dynamic process, catalyzed by SUMO-specific activating (E1), conjugating (E2) and ligating (E3) enzymes, and reversed by a family of SUMO-specific proteases (SENPs). Small ubiquitin-like modifier 1 (SUMO1) is a member of the superfamily of ubiquitin-like proteins. Despite its structural similarity with ubiquitin, SUMO1 does not seem to play any role in protein degradation. SUMO1 plays an important role in modulation of NOX activity required for ROS generation. SUMO1 haploinsufficiency results in cleft lip and palate in animal models. SUMO1 gene variation in human non-syndromic cleft lip with or without cleft palate (NSCLP) development. SUMO-1 may be useful as a novel target for therapy in oral squamous cell carcinoma (SCC) as well as a clinical indicator for tumor recurrence together with Mdm2.

      大鼠 SUMO1/SUMO-1 cdna-clone 参考资料
    • Kim HJ, et al. (2011) SUMO1 attenuates stress-induced ROS generation by inhibiting NADPH oxidase 2. Biochem Biophys Res Commun. 410(3): 555-62.
    • Zuo Y, et al. (2009) Small ubiquitin-like modifier protein-specific protease 1 and prostate cancer. Asian J Androl. 11(1): 36-8.
    • Song T, et al. (2008) SUMO1 polymorphisms are associated with non-syndromic cleft lip with or without cleft palate. Biochem Biophys Res Commun. 377(4): 1265-8.
    • Katayama A, et al. (2007) Overexpression of small ubiquitin-related modifier-1 and sumoylated Mdm2 in oral squamous cell carcinoma: possible involvement in tumor proliferation and prognosis. Int J Oncol. 31(3): 517-24.
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