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人 dehydropeptidase-I / DPEP1 基因ORF全长cDNA克隆(表达载体), C-Flag 标签

产品数据评论实验方法
表达宿主: Human Cells  
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13543-H08H-50
13543-H08H-20
50 µg 
20 µg 
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反应性: Human  
应用 : ELISA  
    13543-T16-50
    13543-T16-200
    13543-T16-100
    50 µg 
    200 µg 
    100 µg 
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    反应性: Human  
    应用 : ELISA  
      13543-RP01-400
      13543-RP01-200
      13543-RP01-100
      400 µg 
      200 µg 
      100 µg 
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      dehydropeptidase-I / DPEP1 cdna-clone 研究背景

      Dehydropeptidase-I, also known as DPEP1, is a kidney membrane enzyme. Its expression in normal colonic mucosa is very low, but it is highly expressed in colorectal adenoma and cancer specimens and is negatively correlated with parameters of pathological aggressiveness and poor prognosis. The overexpression of DPEP1 suppressed tumor cells invasiveness and increased sensitivity to chemotherapeutic agent Gemcitabine. Growth factor EGF treatment decreased DPEP1 expression. Dehydropeptidase-I may be a candidate target in PDAC for designing improved treatments. It uses zinc as a cofactor and acts as a disulfide-linked homodimer.

       dehydropeptidase-I / DPEP1 cdna-clone 参考资料
    • Toiyama Y. et al., 2011, J Gastroenterol. 46 (2): 153-63.
    • Zhang G. et al., 2012, PLoS One. 7 (2): e31507.
    • Okamoto T. et al., 2011, Mod Pathol. 24 (2): 267-76.
    • 请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”