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人 Gastric intrinsic factor / GIF 基因ORF全长cDNA克隆(表达载体), C-Flag 标签

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反应性: Human  
应用 : FCM  
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13544-R007-50
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反应性: Human  
应用 : ELISA  
    13544-R016-50
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    13544-R016-1
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    反应性: Human  
    应用 : ELISA  
      13544-RP01-400
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      反应性: Human  
      应用 : WB  IP  
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      13544-R012-50
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      反应性: Human  
      应用 : ELISA  IHC-P  
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      13544-RP02-50
      13544-RP02-200
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      Gastric intrinsic factor / GIF cdna-clone 研究背景

      Gastric intrinsic factor, also known as GIF, belongs to the of the cobalamin transport protein family. It is a glycoprotein produced by the parietal cells of the stomach. Gastric intrinsic factor plays a key role in the absorption of vitamin B12 on in the small intestine. Vitamin B12 bounds to haptocorrin after entry into the stomach. The resulting complex enters the duodenum, where pancreatic enzymes digest haptocorrin. In the less acidic environment of the small intestine, B12 can then bind to gastric intrinsic factor. This new complex travels to the ileum, where special epithelial cells endocytose them. Inside the cell, B12 dissociates once again and binds to another protein, transcobalamin II. The new complex can exit the epithelial cells to enter the liver.

       Gastric intrinsic factor / GIF cdna-clone 参考资料
    • Gerdin AK. (2010) The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice. Acta Opthalmologica. 88:925-7.
    • AU - Berlin H, et al. (1968) ORAL TREATMENT OF PERNICIOUS ANEMIA WITH HIGH DOSES OF VITAMIN B12 WITHOUT INTRINSIC FACTOR. Acta Medica Scandinavica. 184(1-6):247-58.
    • Hewitt JE, et al. (1991) Human gastric intrinsic factor: characterization of cDNA and genomic clones and localization to human chromosome 11. Genomics. 10(2):432-40.
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