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人 Uteroglobin/SCGB1A1 基因ORF全长cDNA克隆(表达载体), N-Flag 标签

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描述: Active  
表达宿主: Human Cells  
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10808-H08H-50
10808-H08H-100
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描述: Active  
表达宿主: Human Cells  
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50291-M08H-50
50291-M08H-5
50291-M08H-100
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反应性: Human  
应用 : ELISA  
    10808-RP02-50
    10808-RP02-200
    10808-RP02-100
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    反应性: Human  
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    10808-R135-50
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    反应性: Human  
    应用 : IHC-P  
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    10808-MM06-50
    10808-MM06-200
    10808-MM06-100
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    反应性: Human  
    应用 : ELISA  
      10808-RP01-400
      10808-RP01-200
      10808-RP01-100
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      反应性: Human  
      应用 : ELISA  
        10808-R030-50
        10808-R030-100
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        反应性: Mouse  
        应用 : ELISA  
          50291-R027-50
          50291-R027-100
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          反应性: Mouse  
          应用 : ELISA  
            50291-R016-50
            50291-R016-100
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            反应性: Mouse  
            应用 : ELISA  
              50291-T16-50
              50291-T16-200
              50291-T16-100
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              反应性: Mouse  
              应用 : IHC-P  
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              50291-R122-50
              50291-R122-100
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              100 µg 
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              反应性: Mouse  
              应用 : ELISA  
                50291-RP01-400
                50291-RP01-200
                50291-RP01-100
                400 µg 
                200 µg 
                100 µg 
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                Uteroglobin/SCGB1A1 cdna-clone 研究背景

                Uteroglobin (UG), also known as Secretoglobin 1A member 1 (SCGB1A1), Blastokinin, Clara cell secretor protein (CCSP) or Clara cell-specific 10-kDa protein (CC10), is the founding member of the secretoglobin family of small, secreted, disulfide-bridged dimeric proteins found only in mammals. This protein is mainly expressed in lung, with anti-inflammatory/immunomodulatory properties. Previous in vitro studies demonstrated that CCAAT/enhancer-binding proteins (C/EBPs) are the major transcription factors for the regulation of SCGB1A1 gene expression, whereas FOXA1 had a minimum effect on the transcription. Uteroglobin is a multifunctional protein with antiinflammatory/immunomodulatory properties. Uteroglobin inhibits soluble phospholipase A(2) activity and binds and perhaps sequesters hydrophobic ligands such as progesterone, retinols, polychlorinated biphenyls, phospholipids, and prostaglandins. In addition to its antiinflammatory activities, Uteroglobin manifests antichemotactic, antiallergic, antitumorigenic, and embryonic growth-stimulatory activities. The tissue-specific expression of the Uteroglobin gene is regulated by several steroid hormones, although a nonsteroid hormone, prolactin, further augments its expression in the uterus. Based on its anti-inflammatory and antiallergic properties, Uteroglobin is a potential drug target. The mechanism of Uteroglobin action is likely to be even more complex as it also functions via a putative receptor-mediated pathway.

                 Uteroglobin/SCGB1A1 cdna-clone 参考资料
              • Mukherjee AB, et al. (1999). Uteroglobin: a novel cytokine? Cell Mol Life Sci. 55(5): 771-87.
              • Klug J, et al. (2000). Uteroglobin/Clara cell 10-kDa family of proteins: nomenclature committee report. Ann. N. Y. Acad. Sci. 923: 348-54.
              • Laukaitis CM, et al. (2005). Evolution of the secretoglobins: a genomic and proteomic view. Biological Journal of the Linnean Society. 84 (3): 493-501.
              • Mukherjee AB, et al. (2007). Uteroglobin: a steroid-inducible immunomodulatory protein that founded the Secretoglobin superfamily. Endocr Rev. 28(7): 707-25.
              • Kido T, et al. (2011). FOXA1 plays a role in regulating secretoglobin 1a1 expression in the absence of CCAAT/enhancer binding protein activities in lung in vivo. Am J Physiol Lung Cell Mol Physiol. 300(3): L441-52.
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