The common gamma-chain family consists of IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21 and was named for binding of these factors to the common gamma-chain receptor. They act mainly as growth and proliferation factors for progenitors and mature cells and also have roles in lineage-specific cell differentiation.
Sino Biological offers quality reagents for research on common gamma-chain family, including: recombinant proteins, antibodies, ELISA kits, ORF cDNA clones, and more.
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Common Gamma-Chain Cytokine Family
The common gamma chain (γc) cytokine family comprises interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15 and IL-21, named after the γc subunit (CD132) shared by receptor complexes for these cytokines. Common gamma-chain cytokine signals provide pro-survival cues, inhibit pro-apoptotic signals, upregulate metabolic activities and promote expression of select transcription factors, which determine lineage fate and maturation of lymphocyte subsets.
Common Gamma-Chain Receptor Family
Among all cytokine receptors, none has such a profound and broad effect on the adaptive immune system as the gamma-chain cytokine receptor. IL-4, IL-7, IL-9 and IL-21 bind a heterodimeric receptor comprised of the γc and the specific receptor subunits, IL-4R, IL-7R (CD127), IL-9R and IL-21R chain, respectively. IL-2 and IL-15 bind a heterotrimeric receptor composed of the specific IL-2R (CD25) or IL-15R chain, and the shared IL-2/15R (CD122) and γc chains.
The IL-17 receptor family now consists of 5 members, IL-17RA, IL-17RB, IL-17RC, IL-17RD and IL-17RE, all of which, like their ligands, share sequence homology. Each of these members is a subunit that needs to associate with another one to form the functional receptor. The subunit IL-17RA is ubiquitous, and is encoded by a gene situated on chromosome 22, while others are encoded by a cluster on chromosome 3. It is also a common co-receptor subunit for other members of the IL-17 family.
The following are outlines of "IL-17 Receptor Family Review Page", which briefly introduce each IL-1 family ligand. If you want more details, please click here.