Anti-Cyclophilin A Antibody

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Anti-Cyclophilin A Antibody (Rabbit Polyclonal 抗体) 产品信息

产品名称
Anti-Cyclophilin A Antibody
经验证的应用
ELISA
交叉反应
Reacts with: Mouse
特异性
Mouse Cyclophilin A
免疫原
Recombinant Mouse Cyclophilin A / PPIA protein (Catalog#50296-M08E)
制备方法
Produced in rabbits immunized with purified, recombinant Mouse Cyclophilin A / PPIA (rM Cyclophilin A / PPIA; Catalog#50296-M08E; NP_032933.1; Met 1-Leu 164). Cyclophilin A / PPIA specific IgG was purified by Mouse Cyclophilin A / PPIA affinity chromatography.
来源
Polyclonal Rabbit IgG
纯化
Protein A & Antigen Affinity
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Cyclophilin A Antibody (Rabbit Polyclonal 抗体) 经验证的应用

应用 推荐稀释比/用量
ELISA 1:5000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Cyclophilin A Antibody: 别称

Anti-2700098C05 Antibody; Anti-Cphn Antibody; Anti-CyP-18 Antibody; Anti-CypA Antibody

Cyclophilin A 背景信息

Peptidyl-prolyl cis-trans isomerase A, also known as PPIase A, Rotamase A, Cyclophilin A, Cyclosporin A-binding protein, PPIA and CYPA, is a cytoplasm protein which belongs to thecyclophilin-type PPIase family and PPIase A subfamily. Cyclophilins (CyPs) are a family of proteins found in organisms ranging from prokaryotes to humans. These molecules exhibit peptidyl-prolyl isomerase activity, suggesting that they influence the conformation of proteins in cells. PPIA / Cyclophilin A accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. PPIA / Cyclophilin A is secreted by vascular smooth muscle cells in response to inflammatory stimuli, and could thus contribute to atherosclerosis. It is not essential for mammalian cell viability. PPIA / Cyclophilin A can interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions.
全称
peptidylprolyl isomerase A (cyclophilin A)
参考文献
  • Haendler B., et al.,(1987), Complementary DNA for human T-cell cyclophilin. EMBO J. 6:947-950.
  • Haendler B., et al., (1990), Characterization of the human cyclophilin gene and of related processed pseudogenes.Eur. J. Biochem. 190:477-482.
  • Ota T., et al.,(2004), Complete sequencing and characterization of 21,243 full-length human cDNAs.Nat. Genet. 36:40-45.
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