GBA3: GBA3 Protein | GBA3 Antibody

GBA3 Background

Cytosolic beta-glucosidase, also known as Cytosolic beta-glucosidase-like protein 1, GBA3, CBG and CBGL1 is a cytoplasm protein which belongs to the glycosyl hydrolase 1 family and Klotho subfamily. GBA3 / CBGL1 is a glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. GBA3 / CBGL1 is present in small intestine (at protein level). GBA3 / CBGL1 is expressed in liver, small intestine, colon, spleen and kidney. GBA3 / CBGL1 is down-regulated in renal cell carcinomas and hepatocellular carcinomas. GBA3 / CBGL1 is able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens. GBA3 / CBGL1 possesses beta-glycosylceramidase activity and may be involved in a nonlysosomal catabolic pathway of glycosylceramide.

Reference for GBA3

  • Yahata K., et al.,(2000), Molecular cloning and expression of a novel klotho-related protein. J. Mol. Med. 78:389-394.
  • de Graaf M., et al., (2001), Cloning and characterization of human liver cytosolic beta-glycosidase.Biochem. J. 356:907-910.
  • Berrin J.-G., et al.,(2002), Functional expression of human liver cytosolic beta-glucosidase in Pichia pastoris. Insights into its role in the metabolism of dietary glucosides.Eur. J. Biochem. 269:249-258.

GBA3 Protein

GBA3 protein function

Glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. Able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens. Possesses beta-glycosylceramidase activity and may be involved in a nonlysosomal catabolic pathway of glycosylceramide. {ECO:0000269|PubMed:11784319, ECO:0000269|PubMed:12594539, ECO:0000269|PubMed:17595169}.

GBA3 protein expression

Tissue specificity

Present in small intestine (at protein level). Expressed in liver, small intestine, colon, spleen and kidney. Down-regulated in renal cell carcinomas and hepatocellular carcinomas.

GBA3 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    469.00
  • Mass (Da)
    53.00

GBA3 Antibody

There are 8 GBA3 antibodies which are validated in multiple tissues with various applications, including FCM, ICC/IF, ELISA. There are 5 GBA3 antibody for FCM, 2 GBA3 antibody for ICC/IF, 3 GBA3 antibody for ELISA. Among all these GBA3 antibodies, there are 2 anti-GBA3 mouse monoclonal antibodies , 4 anti-GBA3 rabbit monoclonal antibodies , 2 anti-GBA3 rabbit polyclonal antibodies . All the GBA3 anbodies are produced in house and all are in stock. GBA3 antibody customerized service is available.

GBA3 Gene

GBA3 gene / cDNA is a protein-coding gene which located on 4p15.2. 5 organisms have orthologs with human gene GBA3.