Anti-DDR1 Antibody

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Anti-DDR1 Antibody (Rabbit Monoclonal 抗体) 产品信息

产品名称
Anti-DDR1 Antibody
经验证的应用
ELISA(Det)
交叉反应
Reacts with: Human
特异性
Human DDR1
免疫原
Recombinant Human DDR1/MCK10/CD167 Protein (Catalog#10730-H08H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Human DDR1/MCK10/CD167 (rh DDR1/MCK10/CD167; Catalog#10730-H08H; NP_001945.3; Met1-Thr416).
来源
Monoclonal Rabbit IgG Clone #017
纯化
Protein A
缓冲液
0.2 μm filtered solution in PBS
偶联物
Unconjugated
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-DDR1 Antibody (Rabbit Monoclonal 抗体) 经验证的应用

Notes
ELISA(Det): This antibody will detect Human DDR1 / MCK10 / CD167 in ELISA pair set (Catalog: # SEK10730). In a sandwich ELISA, it can be used as detection antibody when paired with (Catalog: # 10730-R205).
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-DDR1 Antibody: 别称

Anti-CAK Antibody; Anti-CD167 Antibody; Anti-DDR Antibody; Anti-EDDR1 Antibody; Anti-HGK2 Antibody; Anti-MCK10 Antibody; Anti-NEP Antibody; Anti-NTRK4 Antibody; Anti-PTK3 Antibody; Anti-PTK3A Antibody; Anti-RTK6 Antibody; Anti-TRKE Antibody

DDR1 背景信息

Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 1 (MCK1), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of DDR1/MCK1/CD167 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. DDR1/MCK1/CD167 plays an important role in regulating attachment to collagen, chemotaxis, proliferation, and MMP production in smooth muscle cells. DDR1 functions in a feedforward loop to increase p53 levels and at least some of its effectors. Inhibition of DDR1 function resulted in strikingly increased apoptosis of wild-type p53-containing cells in response to genotoxic stress through a caspase-dependent pathway.
全称
discoidin domain receptor tyrosine kinase 1
参考文献
  • Hou G, et al. (2001) The discoidin domain receptor tyrosine kinase DDR1 in arterial wound repair. J Clin Invest. 107(6): 727-35.
  • Ongusaha PP, et al. (2003) p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop. EMBO J. 22(6): 1289-301.
  • Jönsson M, et al. (2001) Repression of Wnt-5a impairs DDR1 phosphorylation and modifies adhesion and migration of mammary cells. J Cell Sci. 114(11): 2043-53.
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