Recombinant Human DDR1/MCK10/CD167 Protein (Catalog#10730-H08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Human DDR1/MCK10/CD167 (rh DDR1/MCK10/CD167; Catalog#10730-H08H; NP_001945.3; Met1-Thr416).
Monoclonal Rabbit IgG Clone #017
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Anti-DDR1 Antibody (Rabbit Monoclonal 抗体) 经验证的应用
This antibody will detect Human DDR1 / MCK10 / CD167 in ELISA pair set (Catalog: # SEK10730). In a sandwich ELISA, it can be used as detection antibody when paired with (Catalog: # 10730-R205).
Please Note: Optimal concentrations/dilutions should be determined by the end user.
Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 1 (MCK1), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of DDR1/MCK1/CD167 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. DDR1/MCK1/CD167 plays an important role in regulating attachment to collagen, chemotaxis, proliferation, and MMP production in smooth muscle cells. DDR1 functions in a feedforward loop to increase p53 levels and at least some of its effectors. Inhibition of DDR1 function resulted in strikingly increased apoptosis of wild-type p53-containing cells in response to genotoxic stress through a caspase-dependent pathway.