Drug targets for Cancer: CD20

Drug Targets for Cancer: CD20 and Cancer

The cell-surface antigen CD20 is expressed on more than 90% of B-cell lymphomas and chronic lymphocytic leukemias, and on 50% of pre-B-cell acute lymphoblastic leukemia. It is expressed on normal B cells from the pre-B-cell stage to the activated B-cell stage, but is not expressed on stem cells, plasma cells, or cells of other lineages. It is a transmembrane protein that appears to act as a calcium channel and to play an important role in cell-cycle progression and differentiation. Monoclonal antibodies that target the CD20 antigen have been developed, both for diagnostic and therapeutic purposes. The CD20 antigen is appealing for targeted therapy, because it does not shed, modulate, or internalize.

Drug Targets for Cancer: CD20 related Products

Drug targets for cancer: CD20 research reagents

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Drug Targets for Cancer: CD20 Related Reference

McLaughlin P, Grillo-López A J, Link B K, et al. Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program[J]. Journal of clinical oncology, 1998, 16(8): 2825-2833.
Taylor RP, Lindorfer MA. Analyses of CD20 Monoclonal Antibody–Mediated Tumor Cell Killing Mechanisms: Rational Design of Dosing Strategies. Molecular Pharmacology. 2014;86(5):485-491.

Drug Targets for Cancer: CD20 Related Information

Drug Targets for Cancer