Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a cell adhesion molecule, formerly known as CD66a or biliary glycoprotein 1, which belongs to the carcino- embryonic antigen family and a subgroup of the immunoglobu- lin (Ig) superfamily. CEACAM1 is known to be a tumor suppressor, which acts as a regulator of apoptosis. The expression of CEACAM1 is downregulated in malignant tissues derived from colon, breast, prostate and endometrium. On the other hand, upregulation of CEACAM1 is associated with a short survival and metastatic spread in patients with cutaneous malignant melanoma and in lung cancer.
Drug targets for cancer: CEACAM1 research reagents
Other vital drug targets for cancer likeCEACAM1:
Ieda J, Yokoyama S, Tamura K, et al. Re‐expression of CEACAM1 long cytoplasmic domain isoform is associated with invasion and migration of colorectal cancer[J]. International Journal of Cancer, 2011, 129(6): 1351-1361.