IL18R1 ELISA Kit, Human

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IL18R1 ELISA Kit, Human: 产品信息

产品名称
IL18R1 ELISA Kit, Human
检测原理
Solid Phase Sandwich ELISA (quantitative)
偶联物
HRP
检测样品
Serum
灵敏度
3.49 pg/mL
线性范围
7.81-500 pg/mL
特异性
Recognizes both recombinant and natural Human IL18R1
干扰
Preparations of IL18 prepared at 5 ng/mL in a mid-range recombinant human IL18R1 control was assayed for interference. No significant interference was observed.
精密度
  Intra-assay Precision
Sample 1 2 3
N 20 20 20
Mean(pg/mL) 50.00 96.00 199.00
SD 1.76 5.45 8.93
CV(%) 3.5% 5.7% 4.5%
  Inter-assay Precision
Sample 1 2 3
N 20 20 20
Mean(pg/mL) 16.00 53.00 207.00
SD 2.11 4.79 21.69
CV(%) 13.2% 9.1% 10.5%
回收率
The recovery of Human IL18R1 spiked to different levels throughout the range of the assay in related matrices was evaluated.
Sample
serum (n=3)
Average % Recovery
85
Range
83 -90%
线性关系
Serum
  Recovery of detected
1:2 100%
1:4 100%
1:8 107%
1:16 91%
ELISA 试剂盒(即用型)组分
1. 96 well microplate coated with Capture Antibody
2. Detection Antibody conjugated to HRP
3. Standards
4. Wash Buffer Concentrate
5. Dilution Buffer Concentrate
6. Color Reagent A
7. Color Reagent B
8. Stop Solution
产品概述
This IL18R1 ELISA Kit, Human is an enzyme-linked immunosorbent assay for the quantitative measurement of Human IL18R1 protein in Serum . It contains recombinant Human IL18R1, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use.
运输方式
This ELISA Kit is shipped at ambient temperature.
储存条件
Unopened Kit: Store at 2 - 8℃
Opened/Reconstituted Reagents: Please refer to CoA

IL18R1 ELISA Kit, Human: 图片

This standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
This assay recognizes both recombinant and natural Human IL18R1. The factors listed above were prepared at 10 or 50 ng/mL in dilution buffer and assayed for cross-reactivity. No cross -reactivity was observed.
Preparations of IL18 prepared at 5 ng/mL in a mid-range recombinant human IL18R1 control was assayed for interference. No significant interference was observed.

IL18R1 ELISA Kit, Human: 别称

CD218a ELISA Kit, Human; CDw218a ELISA Kit, Human; IL-1Rrp ELISA Kit, Human; IL18RA ELISA Kit, Human; IL1RRP ELISA Kit, Human

IL18R1 背景信息

Interleukin-18 receptor 1 (IL18R1) also known as CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein and CD218a, is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is found expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression is found in Hodgkin disease cell lines. This receptor is specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target. The absence of a genetic association in the IL18R1 gene itself suggests regulation from other parts of the genome, or as part of the inflammatory cascade in multiple sclerosis without a prime genetic cause.
全称
interleukin 18 receptor 1
研究领域
Related Pathways
  • IL1 signaling pathway
    IL1 signaling pathway
参考文献
  • Nadif R, et al.. (2006) IL18 and IL18R1 polymorphisms, lung CT and fibrosis: A longitudinal study in coal miners. Eur Respir J. 28(6): 1100-5.
  • Haralambieva IH, et al.. (2011) Common SNPs/haplotypes in IL18R1 and IL18 genes are associated with variations in hum oral immunity to smallpox vaccination in Caucasians and African Americans. J Infect Dis. 204(3): 433-41.
  • Hulin-Curtis SL, et al.. (2012) Evaluation of IL18 and IL18R1 polymorphisms: genetic susceptibility to knee osteoarthritis. Int J Immunogenet. 39(2): 106-9.
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