IP-10/CXCL10 ELISA Kit, Human

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IP-10/CXCL10 ELISA Kit, Human: 产品信息

产品名称
IP-10/CXCL10 ELISA Kit, Human
检测原理
Solid Phase Sandwich ELISA (quantitative)
偶联物
HRP
检测样品
Serum
灵敏度
1.68 pg/mL
线性范围
3.91-250 pg/mL
特异性
Recognizes both recombinant and natural Human IP-10/CXCL10
干扰
Preparations of the following factors at 50 ng/mL in a mid-range recombinant Human CXCL10 control were assayed for interference. No significant interference was observed.
ELISA 试剂盒(即用型)组分
1. 96 well microplate coated with Capture Antibody
2. Detection Antibody conjugated to HRP
3. Standards
4. Wash Buffer Concentrate
5. Dilution Buffer Concentrate
6. Color Reagent A
7. Color Reagent B
8. Stop Solution
产品概述
This IP-10/CXCL10 ELISA Kit, Human is an enzyme-linked immunosorbent assay for the quantitative measurement of Human IP-10/CXCL10 protein in Serum . It contains recombinant Human IP-10/CXCL10, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use.
运输方式
This ELISA Kit is shipped at ambient temperature.
储存条件
Unopened Kit: Store at 2 - 8℃
Opened/Reconstituted Reagents: Please refer to CoA

IP-10/CXCL10 ELISA Kit, Human: 图片

This standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
This assay recognizes both recombinant and natural Human CXCL10. The factors listed below were prepared at 50 ng/mL in dilution buffer and assayed for cross-reactivity. No cross-reactivity was observed.

IP-10/CXCL10 ELISA Kit, Human: 别称

C7 ELISA Kit, Human; crg-2 ELISA Kit, Human; gIP-10 ELISA Kit, Human; IFI10 ELISA Kit, Human; INP10 ELISA Kit, Human; IP-10 ELISA Kit, Human; mob-1 ELISA Kit, Human; SCYB10 ELISA Kit, Human

IP-10/CXCL10 背景信息

(C-X-C motif) ligand (CXCL)10 (CXCL10) belongs to the ELR(-) CXC subfamily chemokine. CXCL10/IP-10 exerts its function through binding to chemokine (C-X-C motif) receptor 3 (CXCR3), a seven trans-membrane receptor coupled to G proteins. CXCL10/IP-10 and its receptor, CXCR3, appear to contribute to the pathogenesis of many autoimmune diseases, organ specific (such as type 1 diabetes, autoimmune thyroiditis, Graves' disease and ophthalmopathy), or systemic (such as rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, mixed cryoglobulinemia, Sjögren syndrome, or systemic sclerosis). CXCL10/IP-10 is secreted by several cell types including endothelial cells, fibroblasts, keratinocytes, thyrocytes, preadipocytes, etc. Determination of high level of CXCL10/IP-10 in peripheral fluids is therefore a marker of host immune response.
全称
chemokine (C-X-C motif) ligand 10
研究领域
Related Pathways
  • IL17 signaling pathway
    IL17 signaling pathway
参考文献
  • O'Donovan N, et al. (1999) Physical mapping of the CXC chemokine locus on human chromosome 4. Cytogenet. Cell Genet. 84(1-2):39-42.
  • Swaminathan GJ, et al. (2003) Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine. Structure. 11(5):521-32.
  • Booth V, et al. (2002) The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions. Biochemistry. 41(33):10418-25.
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