Neuropilin-2 ELISA Kit, Human

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Neuropilin-2 ELISA Kit, Human: 产品信息

产品名称
Neuropilin-2 ELISA Kit, Human
检测原理
Solid Phase Sandwich ELISA (quantitative)
偶联物
HRP
检测样品
Serum
灵敏度
42.98 pg/mL
线性范围
125-8000 pg/mL
特异性
Recognizes both recombinant and natural Human Neuropilin-2
精密度
  Intra-assay Precision
Sample 1 2 3
N 20 20 20
Mean(pg/mL) 1,525.75 3,325.60 6,344.16
SD 47.76 75.09 160.12
CV(%) 3.1% 2.3% 2.5%
  Inter-assay Precision
Sample 1 2 3
N 20 20 20
Mean(pg/mL) 1,277.42 2,999.30 5,835.64
SD 167.50 197.14 374.53
CV(%) 13.1% 6.6% 6.4%
回收率
The recovery of Human NRP2 spiked to different levels throughout the range of the assay in related matrices was evaluated.
Sample
serum (n=3)
Average % Recovery
106
Range
105 -109%
线性关系
Serum
  Recovery of detected
1:2 97%
1:4 103%
1:8 100%
1:16 96%
ELISA 试剂盒(即用型)组分
1. 96 well microplate coated with Capture Antibody
2. Detection Antibody conjugated to HRP
3. Standards
4. Wash Buffer Concentrate
5. Dilution Buffer Concentrate
6. Color Reagent A
7. Color Reagent B
8. Stop Solution
产品概述
This Neuropilin-2 ELISA Kit, Human is an enzyme-linked immunosorbent assay for the quantitative measurement of Human Neuropilin-2 protein in Serum . It contains recombinant Human Neuropilin-2, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use.
运输方式
This ELISA Kit is shipped at ambient temperature.
储存条件
Unopened Kit: Store at 2 - 8℃
Opened/Reconstituted Reagents: Please refer to CoA

Neuropilin-2 ELISA Kit, Human: 图片

This standard curve is only for demonstration purposes. A standard curve should be generated for each assay.

Neuropilin-2 ELISA Kit, Human: 别称

Neuropilin-2 ELISA Kit, Human; NP2 ELISA Kit, Human; NPN2 ELISA Kit, Human; PRO2714 ELISA Kit, Human; VEGF165R2 ELISA Kit, Human

Neuropilin-2 背景信息

Neuropilin-2 (NRP-2) which is related to NRP-1, is a type I? transmembrane glycoprotein and has the structure characteristic with five main extracellular domains: two complement binding (CUB) domains, two coagulation factor V/VIII homology domains, and a MAM (meprin, tyrosine phosphatase domain) region. NRP-2 is a receptor capable of binding two disparate ligands, classⅢ semaphorins (SEMA) and vascular endothelial growth factors (VEGF), and thus regulates two diverse systems by activating cellular signaling pathways via interacting with other cell surface receptors such as VEGF receptors and plexins. NRP-2 is well known for its role in facilitating axonal guidance during the development of the neuronal system, and additionally, it is also expressed in vascular endothelial cells and lymphatic endothelium where it affects proliferation, migration, angiogenesis, as well as formation of small lymphatic vessels and capillaries. Recent study has identified NRP-2 as a polysialylated protein expressed in human dendritic cells and modulates DC-T cell Interactions. Nearly all tumor cells express neuropilins and NRP-2 is predominantly expressed in neuronal tumors and melanomas. Furthermore, it is suggested that as the specific ligand for NRP-2, SEMA 3F inhibits tumor angiogenesis and metastasis.
全称
neuropilin 2
参考文献
  • Chen H. et al., 1997, Neuron. 19: 547-59.
  • Bielenberg DR. et al., 2006, Exp Cell Res. 312: 584-93.
  • Yuan L. et al., 2002, Development. 129: 4797-806.
  • Benoit F. et al., 2006, Blood. 108: 1243-50.
  • Sabrina C. et al., 2007, J Biol Chem. 282: 30346-56.
  • Gray MJ. et al., 2008, J Natl Cancer Inst. 100: 109-20.
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