SELL/CD62L ELISA Kit, Human

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SELL/CD62L ELISA Kit, Human: 产品信息

产品名称
SELL/CD62L ELISA Kit, Human
检测原理
Solid Phase Sandwich ELISA (quantitative)
偶联物
HRP
检测样品
Serum
灵敏度
2.41 pg/mL
线性范围
12.5-800 pg/mL
特异性
Recognizes both recombinant and natural Human SELL/CD62L
精密度
  Intra-assay Precision
Sample 1 2 3
N 20 20 20
Mean(pg/mL) 143.08 317.08 559.48
SD 5.01 6.64 15.56
CV(%) 3.5% 2.1% 2.8%
  Inter-assay Precision
Sample 1 2 3
N 20 20 20
Mean(pg/mL) 143.69 302.79 525.72
SD 12.40 11.13 6.63
CV(%) 8.6% 3.7% 1.3%
回收率
The recovery of Human SELL spiked to different levels throughout the range of the assay in related matrices was evaluated.
Sample
serum (n=3)
Average % Recovery
106
Range
94 -116%
线性关系
Serum
  Recovery of detected
1:2 98%
1:4 99%
1:8 91%
1:16 72%
ELISA 试剂盒(即用型)组分
1. 96 well microplate coated with Capture Antibody
2. Detection Antibody conjugated to HRP
3. Standards
4. Wash Buffer Concentrate
5. Dilution Buffer Concentrate
6. Color Reagent A
7. Color Reagent B
8. Stop Solution
产品概述
This SELL/CD62L ELISA Kit, Human is an enzyme-linked immunosorbent assay for the quantitative measurement of Human SELL/CD62L protein in Serum . It contains recombinant Human SELL/CD62L, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use.
运输方式
This ELISA Kit is shipped at ambient temperature.
储存条件
Unopened Kit: Store at 2 - 8℃
Opened/Reconstituted Reagents: Please refer to CoA

SELL/CD62L ELISA Kit, Human: 图片

This standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
This assay recognizes both recombinant and natural Human SELL. The factors listed below were prepared at 50 ng/mL in dilution buffer and assayed for cross-reactivity. No cross-reactivity was observed.

SELL/CD62L ELISA Kit, Human: 别称

CD62L ELISA Kit, Human; LAM1 ELISA Kit, Human; LECAM1 ELISA Kit, Human; LEU8 ELISA Kit, Human; LNHR ELISA Kit, Human; LSEL ELISA Kit, Human; LYAM1 ELISA Kit, Human; PLNHR ELISA Kit, Human; TQ1 ELISA Kit, Human

SELL/CD62L 背景信息

L-selectin (SELL), also known as CD62L, is a key adhesion molecule that regulates both the migration of leukocytes at sites of inflammation and the recirculation of lymphocytes between blood and lymphoid tissues. It belongs to the selectin family of proteins, and consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. L-selectin is the only selectin expressed on leukocytes and mediates a number of leukocyte-endothelial interactions. L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point. L-selectin-mediated lymphocyte recirculation is required for maintaining the appropriate tissue distribution of lymphocyte subpopulations including naïve and effector subsets such as regulatory T cells. In addition, L-selectin-mediated entry into peripheral lymph nodes is required for optimal induction of lymphocyte homeostatic proliferation during lymphopenia. Importantly, L-selectin has been shown to have both adhesive and signaling functions during leukocyte migration. L-selectin has also been shown to mediate leukocyte recruitment during chronic inflammatory and autoimmune diseases and thus is a potential therapeutic target for drug development.
全称
selectin L
参考文献
  • Smalley DM, et al. (2005) L-selectin: mechanisms and physiological significance of ectodomain cleavage. J Cell Mol Med. 9(2): 255-66.
  • Grailer JJ, et al. (2009) L-selectin: role in regulating homeostasis and cutaneous inflammation. J Dermatol Sci. 56(3): 141-7.
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