TROP2 ELISA Kit, Human

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TROP2 ELISA Kit, Human: 产品信息

产品名称
TROP2 ELISA Kit, Human
检测原理
Solid Phase Sandwich ELISA (quantitative)
偶联物
HRP
检测样品
Serum
灵敏度
7.23 pg/mL
线性范围
23.44-1500 pg/mL
特异性
Recognizes both recombinant and natural Human TROP2
精密度
  Intra-assay Precision
Sample 1 2 3
N 20 20 20
Mean(pg/mL) 380.82 739.90 1,367.44
SD 35.86 95.39 182.47
CV(%) 9.4% 12.9% 13.3%
  Inter-assay Precision
Sample 1 2 3
N 20 20 20
Mean(pg/mL) 382.93 782.32 1,508.49
SD 50.36 58.55 112.92
CV(%) 13.2% 7.5% 7.5%
回收率
The recovery of Human TACSTD2 spiked to different levels throughout the range of the assay in related matrices was evaluated.
Sample
serum (n=3)
Average % Recovery
109
Range
107-111%
线性关系
Serum
  Recovery of detected
1:2 95%
1:4 105%
1:8 112%
1:16 100%
ELISA 试剂盒(即用型)组分
1. 96 well microplate coated with Capture Antibody
2. Detection Antibody conjugated to HRP
3. Standards
4. Wash Buffer Concentrate
5. Dilution Buffer Concentrate
6. Color Reagent A
7. Color Reagent B
8. Stop Solution
产品概述
This TROP2 ELISA Kit, Human is an enzyme-linked immunosorbent assay for the quantitative measurement of Human TROP2 protein in Serum . It contains recombinant Human TROP2, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use.
运输方式
This ELISA Kit is shipped at ambient temperature.
储存条件
Unopened Kit: Store at 2 - 8℃
Opened/Reconstituted Reagents: Please refer to CoA

TROP2 ELISA Kit, Human: 图片

This standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
This assay recognizes both recombinant and natural Human TROP2. The factors listed below were prepared at 50 ng/mL in dilution buffer and assayed for cross-reactivity. No cross-reactivity was observed.

TROP2 ELISA Kit, Human: 别称

EGP-1 ELISA Kit, Human; EGP1 ELISA Kit, Human; GA733-1 ELISA Kit, Human; GA7331 ELISA Kit, Human; GP50 ELISA Kit, Human; M1S1 ELISA Kit, Human; TACD2 ELISA Kit, Human; TROP-2 ELISA Kit, Human; TROP2 ELISA Kit, Human

TROP2 背景信息

TROP-2, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate.
全称
tumor-associated calcium signal transducer 2
研究领域
参考文献
  • Ripani E, et al. (1998) Human Trop-2 is a tumor-associated calcium signal transducer. Int J Cancer. 76(5): 671-6.
  • Wang J, et al. (2008) Identification of Trop-2 as an oncogene and an attractive therapeutic target in colon cancers. Mol Cancer Ther. 7(2): 280-5.
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