VEGFR3/FLT4 ELISA Kit, Human

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VEGFR3/FLT4 ELISA Kit, Human: 产品信息

产品名称
VEGFR3/FLT4 ELISA Kit, Human
检测原理
Solid Phase Sandwich ELISA (quantitative)
偶联物
HRP
检测样品
Serum
灵敏度
35 pg/mL
线性范围
46.88-3000 pg/mL
特异性
Recognizes both recombinant and natural Human VEGFR3/FLT4
干扰
Recombinant human VEGFC does not cross-react in this assay but does interfere at concentrations greater than 0.5 ng/mL.
精密度
  Intra-assay Precision
Sample 1 2 3
N 20 20 20
Mean(pg/mL) 0.44 1.02 2.05
SD 0.03 0.04 0.10
CV(%) 6.1% 4.1% 5.1%
  Inter-assay Precision
Sample 1 2 3
N 20 20 20
Mean(pg/mL) 0.48 1.00 2.05
SD 0.04 0.04 0.07
CV(%) 8.6% 4.3% 3.4%
回收率
The recovery of Human FLT4 spiked to different levels throughout the range of the assay in related matrices was evaluated.
Sample
serum (n=4)
Average % Recovery
76
Range
74-80%
线性关系
Serum
  Recovery of detected
1:2 97%
1:4 98%
1:8 102%
1:16 116%
ELISA 试剂盒(即用型)组分
1. 96 well microplate coated with Capture Antibody
2. Detection Antibody conjugated to HRP
3. Standards
4. Wash Buffer Concentrate
5. Dilution Buffer Concentrate
6. Color Reagent A
7. Color Reagent B
8. Stop Solution
产品概述
This VEGFR3/FLT4 ELISA Kit, Human is an enzyme-linked immunosorbent assay for the quantitative measurement of Human VEGFR3/FLT4 protein in Serum . It contains recombinant Human VEGFR3/FLT4, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use.
运输方式
This ELISA Kit is shipped at ambient temperature.
储存条件
Unopened Kit: Store at 2 - 8℃
Opened/Reconstituted Reagents: Please refer to CoA

VEGFR3/FLT4 ELISA Kit, Human: 图片

This standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
This assay recognizes both recombinant and natural Human VEGFR3. The factors listed above were prepared at 50 ng/mL in dilution buffer and assayed for cross-reactivity. No cross-reactivity was observed.
Recombinant human VEGFC does not cross-react in this assay but does interfere at concentrations greater than 0.5 ng/mL.

VEGFR3/FLT4 ELISA Kit, Human: 别称

FLT-4 ELISA Kit, Human; FLT-41 ELISA Kit, Human; FLT41 ELISA Kit, Human; LMPH1A ELISA Kit, Human; PCL ELISA Kit, Human; VEGF Receptor 3 ELISA Kit, Human; VEGFR-3 ELISA Kit, Human; VEGFR3 ELISA Kit, Human

VEGFR3/FLT4 背景信息

Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). The VEGFR3 protein is expressed mainly on lymphatic vessels but it is also up-regulated in tumor angiogenesis. Mutations in VEGFR3 have been identified in patients with primary lymphoedema. The VEGF-C/VEGF-D/VEGFR3 signaling pathway may provide a target for antilymphangiogenic therapy in prostate cancer, breast cancer, gastric cancer, lung cancer, non-small cell lung cancer (NSCLC), and so on.
全称
fms related tyrosine kinase 4
参考文献
  • Shushanov S, et al. (2000)VEGFc and VEGFR3 expression in human thyroid pathologies. Int J Cancer.86(1): 47-52.
  • Iljin K, et al. (2001) VEGFR3 gene structure, regulatory region, and sequence polymorphisms. FASEB J. 15(6): 1028-36.
  • Liu XE, et al. (2004) Expression and significance of VEGF-C and FLT-4 in gastric cancer. World J Gastroenterol. 10(3): 352-5.
  • Stearns ME, et al. (2004) Expression of a flt-4 (VEGFR3) splicing variant in primary human prostate tumors. VEGF D and flt-4t(Delta773-1081) overexpression is diagnostic for sentinel lymph node metastasis. Lab Invest. 84(6): 785-95.
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