FGF21 Protein, Mouse, Recombinant (His Tag)

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FGF21 Protein, Mouse, Recombinant (His Tag): 产品信息

纯度
> 85 % as determined by SDS-PAGE
内毒素
< 1.0 EU per μg of the protein as determined by the LAL method
生物活性
Testing in progress
蛋白构建
A DNA sequence encoding the mouse FGF21 (Q9JJN1) (Met 1-Ser 210) was expressed, with a polyhistidine tag at the C-terminus.
NCBI Reference No.
表达宿主
HEK293 Cells
种属
Mouse
预测 N 端
Ala 29
分子量
The secreted recombinant mouse FGF21 consists of 193 amino acids and has a calculated molecular mass of 21.3 kDa. As a result of glycosylation, the apparent molecular mass of rm FGF21 is approximately 25 kDa in SDS-PAGE under reducing conditions.
缓冲液
Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
运输方式
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
稳定性 & 储存条件
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
复溶
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

FGF21 Protein, Mouse, Recombinant (His Tag): 图片

FGF21 Protein, Mouse, Recombinant (His Tag): 别称

FGF-21 Protein, Mouse

FGF21 背景信息

Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-21 has a hydrophobic amino terminus, which is a typical signal sequence, and appears to be a secreted protein. The metabolic regulator fibroblast growth factor 21 (FGF21) has antidiabetic properties in animal models of diabetes and obesity. FGF21 is a novel adipokine associated with obesity-related metabolic complications in humans. The paradoxical increase of serum FGF21 in obese individuals, which may be explained by a compensatory response or resistance to FGF21, warrants further investigation. FGF-21, which we have identified as a novel metabolic factor, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes.
全称
fibroblast growth factor 21
参考文献
  • Zhang X, et al. (2008) Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes. 57(5): 1246-53.
  • Lundåsen T, et al. (2007) PPARalpha is a key regulator of hepatic FGF21. Biochem Biophys Res Commun. 360(2): 437-40.
  • Kharitonenkov A, et al. (2005) FGF-21 as a novel metabolic regulator. J Clin Invest. 115(6): 1627-35.
  • Endoplasmic Reticulum Stress Induces Up-regulation of Hepatic β-Klotho Expression through ATF4 Signaling Pathway
    Author
    Dong, K;Li, H;Zhang, M;Jiang, S;Chen, S;Zhou, J;Dai, Z;Fang, Q;Jia, W;
    Year
    2015
    Journal
    Biochem. Biophys. Res. Commun.
    Application
    cell-based
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