Her2 / ERBB2 Protein, Mouse, Recombinant (His Tag)

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Her2 / ERBB2 Protein, Mouse, Recombinant (His Tag): 产品信息

纯度
> 95 % as determined by SDS-PAGE
内毒素
< 1.0 EU per μg of the protein as determined by the LAL method
生物活性
Testing in progress
蛋白构建
A DNA sequence encoding the mouse ERBB2 (P70424) extracellular domain (Met 1-Thr 653) was expressed, with a C-terminal polyhistidine tag.
NCBI Reference No.
表达宿主
HEK293 Cells
种属
Mouse
预测 N 端
Thr 23
分子量
The secreted recombinant mouse ERBB2 comprises 642 amino acids and has a calculated molecular mass of 71.1 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 100-110 kDa in SDS-PAGE under reducing conditions.
缓冲液
Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
运输方式
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
稳定性 & 储存条件
Samples are stable for up to twelve months from date of receipt at -70℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
复溶
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Her2 / ERBB2 Protein, Mouse, Recombinant (His Tag): 图片

Her2 / ERBB2 Protein, Mouse, Recombinant (His Tag): 别称

c-erbB2 Protein, Mouse; c-neu Protein, Mouse; Erbb-2 Protein, Mouse; HER-2 Protein, Mouse; HER2 Protein, Mouse; l11Jus8 Protein, Mouse; mKIAA3023 Protein, Mouse; Neu Protein, Mouse

Her2 / ERBB2 背景信息

Epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD34, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.
全称
erb-b2 receptor tyrosine kinase 2
参考文献
  • Krawczyk N, et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-24.
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