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 Aurora A/AURKA  抗体

All Aurora A Reagents

Aurora A/AURKA
反应性: Human  
应用 : IHC-P  
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Aurora A/AURKA 相关研究领域

Aurora A/AURKA 相关信号通路

    Aurora A/AURKA 相关蛋白、抗体、cDNA基因、ELISA试剂盒

    Aurora A/AURKA 相关蛋白、抗体、cDNA基因、ELISA试剂盒

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    Aurora A/AURKA 概述&蛋白信息

    Aurora A/AURKA 研究背景

    催化活性: ATP + a protein = ADP + a phosphoprotein. {ECO:0000269|PubMed:12237287, ECO:0000269|PubMed:16337122, ECO:0000269|PubMed:19140666, ECO:0000269|PubMed:19402633}.
    酶调控: ENZYME REGULATION: Activation of CDK1, appears to be an upstream event of AURKA activation. Phosphatase inhibitor-2 (PPP1R2) and TPX2 act also as activators. Inactivated by the G2 checkpoint. Inhibited by GADD45A and p53/TP53, and through dephosphorylation by protein phosphatase type 1 (PP1). MLN8054 is also a potent and selective inhibitor. Activated during the early phase of cilia disassembly in the presence of PIFO. {ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:17360485}.
    亚单位结构: Interacts with FBXL7 (By similarity). Interacts with CPEB1, JTB, TACC1, TPX2, PPP2CA, as well as with the protein phosphatase type 1 (PP1) isoforms PPP1CA, PPP1CB and PPP1CC. Interacts also with its substrates ARHGEF2, BORA, BRCA1, KIF2A, PARD3, and p53/TP53. Interaction with BORA promotes phosphorylation of PLK1. Interacts with PIFO. Interacts with GADD45A, competing with its oligomerization. Interacts (via C-terminus) with AUNIP (via C-terminus). Identified in a complex with AUNIP and NIN. Interacts with FRY; this interaction facilitates AURKA-mediated PLK1 phosphorylation. Interacts with SIRT2. {ECO:0000250, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12237287, ECO:0000269|PubMed:12467573, ECO:0000269|PubMed:14580337, ECO:0000269|PubMed:14603251, ECO:0000269|PubMed:14702041, ECO:0000269|PubMed:14990569, ECO:0000269|PubMed:15966895, ECO:0000269|PubMed:16890155, ECO:0000269|PubMed:17229885, ECO:0000269|PubMed:17488622, ECO:0000269|PubMed:17726514, ECO:0000269|PubMed:18662907, ECO:0000269|PubMed:19140666, ECO:0000269|PubMed:19351716, ECO:0000269|PubMed:19357306, ECO:0000269|PubMed:19402633, ECO:0000269|PubMed:19668197, ECO:0000269|PubMed:19801554, ECO:0000269|PubMed:19812038, ECO:0000269|PubMed:20460379, ECO:0000269|PubMed:20596670, ECO:0000269|PubMed:20643351, ECO:0000269|PubMed:21225229, ECO:0000269|PubMed:22014574, ECO:0000269|PubMed:22753416}.
    亚细胞定位: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the neurite hillock in developing neurons (By similarity). Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase. Colocalized with SIRT2 at centrosome. Moves to the midbody during both telophase and cytokinesis. Associates with both the pericentriolar material (PCM) and centrioles. {ECO:0000250}.
    组织特异性: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.
    诱导: Expression is cell-cycle regulated, low in G1/S, accumulates during G2/M, and decreases rapidly after. {ECO:0000269|PubMed:11790771, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:15987997, ECO:0000269|PubMed:9153231, ECO:0000269|PubMed:9606188}.
    翻译后修饰: Activated by phosphorylation at Thr-288; this brings about a change in the conformation of the activation segment. Phosphorylation at Thr-288 varies during the cell cycle and is highest during M phase. Autophosphorylated at Thr-288 upon TPX2 binding. Thr-288 can be phosphorylated by several kinases, including PAK and PKA. Protein phosphatase type 1 (PP1) binds AURKA and inhibits its activity by dephosphorylating Thr-288 during mitosis. Phosphorylation at Ser-342 decreases the kinase activity. PPP2CA controls degradation by dephosphorylating Ser-51 at the end of mitosis. {ECO:0000269|PubMed:11039908, ECO:0000269|PubMed:11551964, ECO:0000269|PubMed:12390251, ECO:0000269|PubMed:13678582, ECO:0000269|PubMed:14580337, ECO:0000269|PubMed:14990569, ECO:0000269|PubMed:16246726, ECO:0000269|PubMed:17229885, ECO:0000269|PubMed:18662907, ECO:0000269|PubMed:19668197}.; Ubiquitinated by the E3 ubiquitin-protein ligase complex SCF(FBXL7) during mitosis, leading to its degradation by the proteasome. Ubiquitinated by CHFR, leading to its degradation by the proteasome (By similarity). Ubiquitinated by the anaphase-promoting complex (APC), leading to its degradation by the proteasome. {ECO:0000250, ECO:0000269|PubMed:10851084, ECO:0000269|PubMed:11039908}.
    相似的序列: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
    General information above from UniProt

    The Aurora kinase A protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene

    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    Aurora A/AURKA 别称

    AIK,ARK1,AURA,BTAK,STK6,STK7,STK15,AURORA2,PPP1R47, [homo-sapiens]
    IAK,Ark1,Ayk1,IAK1,Stk6,AIRK1,ARK-1,AU019385,AW539821,Aurora-A, [mus-musculus]

    Aurora A/AURKA 相关文献

  • Tamotsu K, Okumura H, Uchikado Y, et al. Correlation of Aurora-A expression with the effect of chemoradiation therapy on esophageal squamous cell carcinoma. BMC Cancer. 2015;15:323. doi:10.1186/s12885-015-1329-3.
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