Text Size:AAA

 CES3/Carboxylesterase 3  抗体

All CES3 Reagents

CES3/Carboxylesterase 3
反应性: Human  
应用 : IHC-P  
11129-R033-50
11129-R033-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
  • Slide 1
反应性: Human  
应用 : ELISA  
11129-RP01-400
11129-RP01-200
11129-RP01-100
400 µg 
200 µg 
100 µg 
Add to Cart
    反应性: Human  
    应用 : ELISA  WB  
    11129-R372-50
    11129-R372-100
    50 µg 
    100 µg 
    Add to Cart
    • Slide 1
    反应性: Human  
    应用 : ELISA  
    11129-RP02-50
    11129-RP02-200
    11129-RP02-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
      反应性: Human  
      应用 : ELISA  
      11129-MM07-50
      11129-MM07-200
      11129-MM07-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart

        Browse CES3/Carboxylesterase 3 Products by

        CES3/Carboxylesterase 3 相关研究领域

        CES3/Carboxylesterase 3 相关信号通路

          CES3/Carboxylesterase 3 相关蛋白、抗体、cDNA基因、ELISA试剂盒

          CES3/Carboxylesterase 3 相关蛋白、抗体、cDNA基因、ELISA试剂盒

          Featured Reagent Products

          CES3/Carboxylesterase 3 概述&蛋白信息

          CES3/Carboxylesterase 3 研究背景

          基因概述: This CES3 gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This CES3 gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010]
          General information above from NCBI
          催化活性: A carboxylic ester + H(2)O = an alcohol + a carboxylate. {ECO:0000255|PROSITE-ProRule:PRU10039}.
          亚细胞定位: Endoplasmic reticulum lumen {ECO:0000250}.
          组织特异性: Expressed in liver, colon and small intestine. {ECO:0000269|PubMed:14581373, ECO:0000269|PubMed:15100172, ECO:0000269|PubMed:15687373}.
          翻译后修饰: N-glycosylated. {ECO:0000269|PubMed:15100172, ECO:0000269|PubMed:19159218}.
          相似的序列: Belongs to the type-B carboxylesterase/lipase family. {ECO:0000305}.
          General information above from UniProt

          Carboxylesterases hydrolyze esters of short-chain fatty acids and have roles in animals ranging from signal transduction to xenobiotic detoxification. In enzymology, a carboxylesterase is an enzyme that catalyzes the chemical reaction: a carboxylic ester + H2O = an alcohol + a carboxylate. Most enzymes from this group belong to the superfamily of hydrolases with alpha/beta protein fold (so called Alpha/beta hydrolase fold), specifically those acting on carboxylic ester bonds. The carboxylesterase family of evolutionarily related proteins (those with clear sequence homology to each other) includes a number of proteins with different substrate specificities, such as acetylcholinesterases. Carboxylesterase 3, also known as Liver carboxylesterase 31 homolog and CES3, is a endoplasmic reticulum lumen which belongs to the type-B carboxylesterase/lipase family. CES3 is involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. CES3 shows low catalytic efficiency for hydrolysis of CPT-11, a prodrug for camptothecin used in cancer therapeutics. CES3 is expressed in liver, colon and small intestine.

          CES3/Carboxylesterase 3 别称

          Carboxylesterase 3,CES3,ES31,FLJ21736,UNQ869/PRO1887, [human]
          Carboxylesterase 3,Ces3,TGH, [mouse]

          CES3/Carboxylesterase 3 相关文献

        • Augusteyn RC. et al.,1969, Biochim Biophys Acta. 171 (1): 128-37.
        • Saito S. et al., 2003, J. Hum. Genet. 48: 249-70.
        • Sanghani SP. et al., 2003, Clin Cancer Res. 9: 4983-91.
        • Sanghani SP. et al., 2004, Drug Metab Dispos. 32: 505-11.
        • Chen R. et al., 2009, J Proteome Res. 8: 651-61.
        • 请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”