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 Carboxypeptidase M/CPM  抗体

All CPM Reagents

Carboxypeptidase M/CPM
反应性: Human  
应用 : ELISA  WB  IP  
11228-R105-50
11228-R105-100
50 µg 
100 µg 
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反应性: Human  
应用 : 
11228-T24-50
11228-T24-200
11228-T24-100
50 µg 
200 µg 
100 µg 
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  • Slide 1
反应性: Human  
应用 : ELISA  
11228-RP01-400
11228-RP01-200
11228-RP01-100
400 µg 
200 µg 
100 µg 
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    反应性: Human  
    应用 : ELISA  
    11228-RP02-50
    11228-RP02-200
    11228-RP02-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
      11228-H08HL-300 

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      Carboxypeptidase M/CPM 相关研究领域

      Carboxypeptidase M/CPM 相关信号通路

        Carboxypeptidase M/CPM 相关蛋白、抗体、cDNA基因、ELISA试剂盒

        Carboxypeptidase M/CPM 相关蛋白、抗体、cDNA基因、ELISA试剂盒

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        Carboxypeptidase M/CPM 概述&蛋白信息

        Carboxypeptidase M/CPM 研究背景

        基因概述: The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene.
        General information above from NCBI
        催化活性: Cleavage of C-terminal arginine or lysine residues from polypeptides.
        辅因子: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; ; Note=Binds 1 zinc ion per subunit.;
        酶调控: ENZYME REGULATION: Inhibited by O-phenanthroline and MGTA and activated by cobalt.
        亚细胞定位: Cell membrane {ECO:0000269|PubMed:12457462}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12457462}.
        相似的序列: Belongs to the peptidase M14 family. {ECO:0000305}.
        General information above from UniProt

        Carboxypeptidase M, also known as CPM, is a membrane-bound arginine/lysine carboxypeptidase which is a member of the carboxypeptidases family. These enzymes remove C-terminal amino acids from peptides and proteins and exert roles in the physiological processes of blood coagulation/fibrinolysis, inflammation, food digestion and pro-hormone and neuropeptide processing. Among the carboxypeptidases CPM is of particular importance because of its constitutive expression in an active form at the surface of specialized cells and tissues in the human body. CPM in the brain appears to be membrane-bound via a phosphatidylinositol glycan anchor. CPM is widely distributed in a variety of tissues and cells. The amino acid sequence of CPM indicated that the C-terminal hydrophobic region might be a signal for membrane attachment via a glycosylphosphatidylinositol (GPI) anchor. CPM is involved in peptide metabolism on both the cell surface and in extracellular fluids. CPM functions not only as a protease but also as a binding partner in cell-surface protein-protein interactions.

        Carboxypeptidase M/CPM 别称

        Carboxypeptidase M,CPM, [human]
        1110060I01Rik,5730456K23Rik,AA589379,Carboxypeptidase M,Cpm,E030045M14Rik,MGC118152, [mouse]
        AA589379,1110060I01Rik,5730456K23Rik,E030045M14Rik, [mus-musculus]

        Carboxypeptidase M/CPM 相关文献

      • Deddish PA. et al., 1990, J Biol Chem. 265 (25): 15083-9.
      • Nagae A. et al., 1992, J Neurochem. 59 (6): 2201-12.
      • Skidgel RA. et al., 1996, Immunopharmacology. 32 (1-3): 48-52.
      • Deiteren K. et al., 2009, Clin Chim Acta. 399 (1-2): 24-39.
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