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 Complement C1s   抗体

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Complement C1s
反应性: Human  
应用 : 
10220-MM04-50
10220-MM04-200
10220-MM04-100
10220-MM04-1
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    反应性: Human  
    应用 : ELISA  
    10220-RP01-400
    10220-RP01-200
    10220-RP01-100
    400 µg 
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    100 µg 
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      反应性: Human  
      应用 : ELISA  
      10220-RP02-50
      10220-RP02-200
      10220-RP02-100
      50 µg 
      200 µg 
      100 µg 
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        反应性: Human  
        应用 : ELISA  
        10220-R006-50
        10220-R006-100
        50 µg 
        100 µg 
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          反应性: Human  
          应用 : 
          10220-MM02-50
          10220-MM02-200
          10220-MM02-100
          10220-MM02-1
          50 µg 
          200 µg 
          100 µg 
          1 mg 
          Add to Cart

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            Complement C1s  相关研究领域

            Complement C1s  相关信号通路

            Complement C1s  相关蛋白、抗体、cDNA基因、ELISA试剂盒

            Complement C1s  相关蛋白、抗体、cDNA基因、ELISA试剂盒

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            Complement C1s  概述&蛋白信息

            Complement C1s  研究背景

            基因概述: This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency
            General information above from NCBI
            催化活性: Cleavage of Arg-|-Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)-|-Lys bond in complement component C2 to form C2a and C2b: the 'classical' pathway C3 convertase. {ECO:0000269|PubMed:11527969}.
            酶调控: ENZYME REGULATION: Inhibited by SERPING1. {ECO:0000269|PubMed:11527969}.
            亚单位结构: C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. Activated C1s is an disulfide-linked heterodimer of a heavy chain and a light chain. {ECO:0000269|PubMed:2007122}.
            翻译后修饰: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. {ECO:0000269|PubMed:2141278}.
            相关疾病 : DISEASE: Complement component C1s deficiency (C1SD) [MIM:613783]: A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. {ECO:0000269|PubMed:11390518}. Note=The disease is caused by mutations affecting the gene represented in this entry.
            相似的序列: Belongs to the peptidase S1 family. {ECO:0000255|PROSITE-ProRule:PRU00274}.; Contains 2 CUB domains. {ECO:0000255|PROSITE-ProRule:PRU00059}.; Contains 1 EGF-like domain. {ECO:0000305}.; Contains 1 peptidase S1 domain. {ECO:0000255|PROSITE-ProRule:PRU00274}.; Contains 2 Sushi (CCP/SCR) domains. {ECO:0000255|PROSITE-ProRule:PRU00302}.
            General information above from UniProt

            Complement is an integral component of the adaptive and innate immune systems and represents one of the major effector systems for the immune responses. The classical complement pathway is triggered by C1, a complex composed of the binding protein C1q and two proenzymes, C1r and C1s. Upon binding of IgG to the head of C1q, C1r undergoes autoactivation and in turn cleaves and activates C1s. C1r and C1s, the proteases responsible for activation and proteolytic activity of the C1 complex of complement, share similar overall structural organizations featuring five nonenzymic protein modules (two CUB modules surrounding a single EGF module, and a pair of CCP modules) followed by a serine protease domain. Besides highly specific proteolytic activities, both proteases exhibit interaction properties associated with their N-terminal regions. In contrast, C1r and C1s widely differ from each other by their glycosylation patterns: both proteins contain Asn-linked carbohydrates, but four glycosylation sites are present on C1r, and only two on C1s. As a highly specific serine protease, C1s executes the catalytic function of the C1 complex: the cleavage of C4 and C2, and thus instigates a sequence of activation steps of other components of the complement system, culminating in the formation of the membrane attack complex which induces cell lysis. Like other complement serine proteases C1s has restricted substrate specificity and it is engaged into specific interactions with other subcomponents of the complement system. The only other protein known to interact with C1s physiologically is SerpinC1, an inhibitor of serine protease, which inhibits C1s activity and thus plays a regulatory role in controlling the function of C1s enzyme.

            Complement C1s  别称

            C1S,FLJ44757, [human]

            Complement C1s  相关文献

          • Arlaud GJ, et al. (1989) Structure and function of C1r and C1s: current concepts. Behring Inst Mitt. (84): 56-64.
          • Thielens NM, et al. (1999) Structure and functions of the interaction domains of C1r and C1s: keystones of the architecture of the C1 complex. Immunopharmacology. 42(1-3): 3-13.
          • Gl P, et al. (2002) C1s, the protease messenger of C1. Structure, function and physiological significance. Immunobiology. 205(4-5): 383-94.
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