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 EphB1/Eph Receptor B1  抗体

All EphB1 Reagents

EphB1/Eph Receptor B1
反应性: Human  
应用 : ELISA  
11963-R022-50
11963-R022-100
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    反应性: Human  
    应用 : ELISA  
    11963-RP02-50
    11963-RP02-200
    11963-RP02-100
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    100 µg 
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      11963-H20B1L-300 
      11963-H08HL-300 

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      EphB1/Eph Receptor B1 相关研究领域

      EphB1/Eph Receptor B1 相关信号通路

      EphB1/Eph Receptor B1 相关蛋白、抗体、cDNA基因、ELISA试剂盒

      EphB1/Eph Receptor B1 相关蛋白、抗体、cDNA基因、ELISA试剂盒

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      EphB1/Eph Receptor B1 概述&蛋白信息

      EphB1/Eph Receptor B1 相关资讯

      EphB1/Eph Receptor B1 研究背景

      基因概述: OMIM - description for EphB1 :
      General information above from NCBI
      催化活性: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. {ECO:0000255|PROSITE-ProRule:PRU10028}.
      亚单位结构: Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts with EPHB6; transphosphorylates EPHB6 to form an active signaling complex. Interacts with PICK1 (By similarity). Interacts (through Tyr-594) with NCK1 (via SH2 domain); activates the JUN cascade to regulate cell adhesion (By similarity). The ligand-activated form interacts (through Tyr-928) with GRB7 and GRB10 (via SH2 domains). The ligand-activated form interacts (residues within the catalytic domain) with GRB2 (via SH2 domain). Interacts with GRB2, SHC1 and SRC; activates the MAPK/ERK cascade to regulate cell migration. Interacts with CBL; regulates receptor degradation through ubiquitination. Interacts with ACP1. {ECO:0000250, ECO:0000269|PubMed:11713248, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:12925710, ECO:0000269|PubMed:18034775, ECO:0000269|PubMed:8798570, ECO:0000269|PubMed:9430661, ECO:0000269|PubMed:9499402}.
      亚细胞定位: Cell membrane {ECO:0000269|PubMed:18034775}; Single-pass type I membrane protein {ECO:0000269|PubMed:18034775}. Early endosome membrane {ECO:0000269|PubMed:18034775}. Cell projection, dendrite {ECO:0000250}.
      组织特异性: Preferentially expressed in brain.
      翻译后修饰: Phosphorylated. Autophosphorylation is stimulated by the ligand EFNB1. Required for interaction with SH2 domain-containing interactors, for activation of the MAPK/ERK and JUN signaling cascades and for ubiquitination by CBL. {ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:18034775, ECO:0000269|PubMed:8798570}.; Ubiquitinated; (EFNB1)ligand-induced poly- and/or multi-ubiquitination by CBL is regulated by SRC and leads to lysosomal degradation. {ECO:0000269|PubMed:18034775}.
      相似的序列: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 Eph LBD (Eph ligand-binding) domain. {ECO:0000255|PROSITE-ProRule:PRU00883}.; Contains 2 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 SAM (sterile alpha motif) domain. {ECO:0000255|PROSITE-ProRule:PRU00184}.
      General information above from UniProt

      Ephrin type-B receptor 1, also known as EphB1, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. EphB2 receptor tyrosine kinase phosphorylates syndecan-2 and that this phosphorylation event is crucial for syndecan-2 clustering and spine formation. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. EphB receptor tyrosine kinases are enriched at synapses, suggesting that these receptors play a role in synapse formation or function. We find that EphrinB binding to EphB induces a direct interaction of EphB with NMDA-type glutamate receptors. This interaction occurs at the cell surface and is mediated by the extracellular regions of the two receptors, but does not require the kinase activity of EphB.

      EphB1/Eph Receptor B1 别称

      NET,ELK,Hek6,EPHT2, [homo-sapiens]
      EPHT2,FLJ37986,Hek6,ELK,EPHB1,NET, [human]
      AW488255,C130099E04Rik,Hek6,9330129L11,Cek6,Elk,Elkh,ENSMUSG00000074119,Ephb1,Net, [mouse]
      Net,Elk,Cek6,Elkh,Hek6,AW488255,9330129L11,C130099E04Rik,ENSMUSG00000074119, [mus-musculus]

      EphB1/Eph Receptor B1 相关文献

    • Dalva MB, et al. (2000) EphB receptors interact with NMDA receptors and regulate excitatory synapse formation. Cell. 103(6): 945-56.
    • Takasu MA, et al. (2002) Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors. Science. 295(5554): 491-5.
    • Adams RH, et al. (1999) Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes Dev. 13(3): 295-306.
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