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 EphB6/Eph Receptor B6  抗体

All EphB6 Reagents

EphB6/Eph Receptor B6
反应性: Human  
应用 : ELISA  
10197-MM07-50
10197-MM07-200
10197-MM07-100
50 µg 
200 µg 
100 µg 
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    反应性: Human  
    应用 : ELISA  
    10197-RP02-50
    10197-RP02-200
    10197-RP02-100
    50 µg 
    200 µg 
    100 µg 
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      反应性: Human  
      应用 : ELISA  
      10197-RP01-400
      10197-RP01-200
      10197-RP01-100
      400 µg 
      200 µg 
      100 µg 
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        反应性: Human  
        应用 : 
        10197-R031-50
        10197-R031-100
        10197-R031-1
        50 µg 
        100 µg 
        1 mg 
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          反应性: Human  
          应用 : ELISA  IHC-P  
          10197-T24-50
          10197-T24-200
          10197-T24-100
          50 µg 
          200 µg 
          100 µg 
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          反应性: Human  
          应用 : ELISA  
          10197-R037-50
          10197-R037-100
          50 µg 
          100 µg 
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            反应性: Human  
            应用 : 
            10197-R026-50
            10197-R026-100
            10197-R026-1
            50 µg 
            100 µg 
            1 mg 
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              10197-H02HL-300 
              10197-HCCHL-300 
              10197-H08HL-300 

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              EphB6/Eph Receptor B6 相关研究领域

              EphB6/Eph Receptor B6 相关信号通路

              EphB6/Eph Receptor B6 相关蛋白、抗体、cDNA基因、ELISA试剂盒

              EphB6/Eph Receptor B6 相关蛋白、抗体、cDNA基因、ELISA试剂盒

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              EphB6/Eph Receptor B6 概述&蛋白信息

              EphB6/Eph Receptor B6 相关资讯

              EphB6/Eph Receptor B6 研究背景

              基因概述: Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands.
              General information above from NCBI
              亚单位结构: Interacts with CBL and EPHB1. Interacts with FYN; this interaction takes place in a ligand-independent manner. {ECO:0000269|PubMed:11713248, ECO:0000269|PubMed:15955811}.
              结构域: The protein kinase domain is predicted to be catalytically inactive. Its extracellular domain is capable of promoting cell adhesion and migration in response to low concentrations of ephrin-B2, but its cytoplasmic domain is essential for cell repulsion and inhibition of migration induced by high concentrations of ephrin-B2.
              亚细胞定位: Membrane; Single-pass type I membrane protein.; Isoform 3: Secreted {ECO:0000305}.
              组织特异性: Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level). Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney. Expressed in breast non invasive tumors but not in metastatic lesions. Isoform 3 is expressed in cell lines of glioblastomas, anaplastic astrocytomas, gliosarcomas and astrocytomas. Isoform 3 is not detected in normal tissues. {ECO:0000269|PubMed:18754880, ECO:0000269|PubMed:19234485, ECO:0000269|PubMed:9207182}.
              翻译后修饰: Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion. {ECO:0000269|PubMed:11713248, ECO:0000269|PubMed:15955811}.
              相似的序列: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 Eph LBD (Eph ligand-binding) domain. {ECO:0000255|PROSITE-ProRule:PRU00883}.; Contains 2 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.; Contains 1 SAM (sterile alpha motif) domain. {ECO:0000255|PROSITE-ProRule:PRU00184}.
              General information above from UniProt

              Ephrins are divided into the ephrin-A (EFNA) class and the ephrin-B (EFNB) class based on their structures and sequence relationships. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB6 is an unusual Eph receptor, lacking catalytic capacity due to alterations in its kinase domain. Interestingly, increased metastatic activity is associated with reduced EphB6 receptor expression in several tumor types, including breast cancer. This emphasizes the potential of EphB6 to act as a suppressor of cancer aggressiveness. EphB6 suppress cancer invasiveness through c-Cbl-dependent signaling, morphologic changes, and cell attachment and indicate that EphB6 may represent a useful prognostic marker and a promising target for therapeutic approaches. EphB6 can both positively and negatively regulate cell adhesion and migration, and suggest that tyrosine phosphorylation of the receptor by an Src family kinase acts as the molecular switch for the functional transition. In addition, Ephrin-B2 may be a physiological ligand for the EphB6 receptor.

              EphB6/Eph Receptor B6 别称

              HEP, [homo-sapiens]
              EphB6,HEP,MGC129910,MGC129911, [human]
              Cekl,Ephb6,Mep, [mouse]
              Cekl,MEP, [mus-musculus]

              EphB6/Eph Receptor B6 相关文献

            • Munthe E, et al. (2000)Ephrin-B2 is a candidate ligand for the Eph receptor, EphB6. FEBS Lett. 466(1): 169-74.
            • Matsuoka H, et al. (2005) Biphasic functions of the kinase-defective Ephb6 receptor in cell adhesion and migration. J Biol Chem. 280(32): 29355-63.
            • Truitt L, et al. (2010) The EphB6 receptor cooperates with c-Cbl to regulate the behavior of breast cancer cells. Cancer Res. 70(3): 1141-53.
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