Text Size:AAA

 FGF21  蛋白

All FGF21 Reagents

FGF21
表达宿主: E. coli  
10911-H07E-50
10911-H07E-20
50 µg 
20 µg 
Add to Cart
  • Slide 1

Browse FGF21 Products by

FGF21 相关研究领域

FGF21 相关信号通路

    FGF21 相关蛋白、抗体、cDNA基因、ELISA试剂盒

    FGF21 相关蛋白、抗体、cDNA基因、ELISA试剂盒

    Featured Reagent Products

    FGF21 概述&蛋白信息

    FGF21 相关资讯

    FGF21 研究背景

    基因概述: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined.
    General information above from NCBI
    亚单位结构: Interacts (via C-terminus) with KLB; this interaction is direct. Interacts with FGFR4. {ECO:0000269|PubMed:15902306, ECO:0000269|PubMed:18829467, ECO:0000269|PubMed:19117008}.
    亚细胞定位: Secreted {ECO:0000305}.
    相似的序列: Belongs to the heparin-binding growth factors family. {ECO:0000305}.
    General information above from UniProt

    Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-21 has a hydrophobic amino terminus, which is a typical signal sequence, and appears to be a secreted protein. The metabolic regulator fibroblast growth factor 21 (FGF21) has antidiabetic properties in animal models of diabetes and obesity. FGF21 is a novel adipokine associated with obesity-related metabolic complications in humans. The paradoxical increase of serum FGF21 in obese individuals, which may be explained by a compensatory response or resistance to FGF21, warrants further investigation. FGF-21, which we have identified as a novel metabolic factor, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes.

    FGF21 别称

    FGF21,Fibroblast Growth Factor 21, [Cynomolgus]
    FGF21,FGF-21,UNQ3115/PRO10196, [human]
    Fgf21,FGF-21, [mouse]

    FGF21 相关文献

  • Zhang X, et al. (2008) Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes. 57(5): 1246-53.
  • Lundåsen T, et al. (2007) PPARalpha is a key regulator of hepatic FGF21. Biochem Biophys Res Commun. 360(2): 437-40.
  • Kharitonenkov A, et al. (2005) FGF-21 as a novel metabolic regulator. J Clin Invest. 115(6): 1627-35.
  • 请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”