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 HIPK2  抗体

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反应性: Human  
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HIPK2 相关研究领域

HIPK2 相关信号通路

HIPK2 相关蛋白、抗体、cDNA基因、ELISA试剂盒

HIPK2 相关蛋白、抗体、cDNA基因、ELISA试剂盒

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HIPK2 概述&蛋白信息

HIPK2 研究背景

催化活性: ATP + a protein = ADP + a phosphoprotein.
亚单位结构: Interacts with CREB1, SIAH1, WSB1, CBX4, TRADD, p53/TP53, TP73, TP63, CREBBP, DAXX, P53DINP1, SKI, SMAD1, SMAD2 and SMAD3, but not SMAD4. Interacts with ATF1, PML, RUNX1, EP300, NKX1-2, NKX2-5, SPN/CD43, UBE2I, HMGA1, CTBP1, AXIN1, NLK, MYB, POU4F1, POU4F2, POU4F3, UBE2I, UBL1 and ZBTB4. Probably part of a complex consisting of p53/TP53, HIPK2 and AXIN1. Interacts with SP100; positively regulates TP53-dependent transcription. {ECO:0000269|PubMed:11032752, ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:11925430, ECO:0000269|PubMed:12220523, ECO:0000269|PubMed:12851404, ECO:0000269|PubMed:12874272, ECO:0000269|PubMed:14647468, ECO:0000269|PubMed:14678985, ECO:0000269|PubMed:17018294, ECO:0000269|PubMed:18093972, ECO:0000269|PubMed:18536714, ECO:0000269|PubMed:19015637, ECO:0000269|PubMed:19448668, ECO:0000269|PubMed:20573984, ECO:0000269|PubMed:20980392, ECO:0000269|PubMed:21145359}.
亚细胞定位: Nucleus, PML body. Cytoplasm. Note=Concentrated in PML/POD/ND10 nuclear bodies. Small amounts are cytoplasmic.
组织特异性: Highly expressed in heart, muscle and kidney. Weakly expressed in a ubiquitous way. Down-regulated in several thyroid and breast tumors. {ECO:0000269|PubMed:11267674, ECO:0000269|PubMed:11798164}.
诱导: Unstable in unstressed cells but stabilized upon DNA damage. Induced by UV irradiation and other genotoxic agents (adriamycin ADR, cisplatin CDDP, etoposide, IR, roscovitin), thus triggering p53/TP53 apoptotic response. Consistutively negatively regulated by SIAH1 and WSB1 through proteasomal degradation. This negative regulation is impaired upon genotoxic stress. Repressed upon hypoxia (often associated with tumors), through MDM2- (an E3 ubiquitin ligases) mediated proteasomal degradation, thus inactivating p53/TP53 apoptotic response. This hypoxia repression is reversed by zinc. The stabilization mediated by DNA damage requires the damage checkpoint kinases ATM and ATR. {ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:18536714, ECO:0000269|PubMed:18974774, ECO:0000269|PubMed:19714248, ECO:0000269|PubMed:20514025}.
翻译后修饰: Autophosphorylation at Tyr-361 in the activation loop activates the kinase and promotes nuclear localization. {ECO:0000250}.; Sumoylated. When conjugated it is directed to nuclear speckles. Desumoylated by SENP1 (By similarity). Sumoylation on Lys-32 is promoted by the E3 SUMO-protein ligase CBX4. {ECO:0000250, ECO:0000269|PubMed:16253240, ECO:0000269|PubMed:17018294, ECO:0000269|PubMed:21145359, ECO:0000269|PubMed:21192925}.; Ubiquitinated by FBXO3, WSB1 and SIAH1, leading to rapid proteasome-dependent degradation. The degradation mediated by FBXO3, but not ubiquitination, is prevented in the presence of PML. The degradation mediated by WSB1 and SIAH1 is reversibly reduced upon DNA damage. {ECO:0000269|PubMed:18093972, ECO:0000269|PubMed:18536714, ECO:0000269|PubMed:18809579}.; Cleaved at Asp-923 and Asp-984 by CASP6 in a p53/TP53-dependent manner. The cleaved form lacks the autoinhibitory C-terminal domain (AID), resulting in a hyperactive kinase, which potentiates p53/TP53 Ser-46 phosphorylation and subsequent activation of the cell death machinery. {ECO:0000269|PubMed:16601678}.
相似的序列: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily. {ECO:0000305}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
General information above from UniProt

HIPK2 别称

PRO0593, [homo-sapiens]
Stank,1110014O20Rik,B230339E18Rik, [mus-musculus]

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