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 HtrA2  抗体

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HtrA2
反应性: Human  
应用 : ELISA  WB  IP  
10619-T52-50
10619-T52-200
10619-T52-100
50 µg 
200 µg 
100 µg 
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反应性: Human  
应用 : ELISA  WB  IHC-P  IP  
10619-T60-50
10619-T60-200
10619-T60-100
50 µg 
200 µg 
100 µg 
Add to Cart
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HtrA2 相关研究领域

HtrA2 相关信号通路

    HtrA2 相关蛋白、抗体、cDNA基因、ELISA试剂盒

    HtrA2 相关蛋白、抗体、cDNA基因、ELISA试剂盒

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    HtrA2 概述&蛋白信息

    HtrA2 研究背景

    基因概述: This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.
    General information above from NCBI
    催化活性: Cleavage of non-polar aliphatic amino acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues.
    亚单位结构: Homotrimer. Interacts with MXI2. Interacts with THAP5 under apoptotic conditions. The mature protein, but not the precursor, binds to BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Interacts with BIRC6/bruce. {ECO:0000269|PubMed:11583623, ECO:0000269|PubMed:11967569, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:19502560}.
    结构域: The mature N-terminus is involved in the interaction with XIAP.; The PDZ domain mediates interaction with MXI2.
    亚细胞定位: Mitochondrion intermembrane space. Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.
    组织特异性: Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.
    翻译后修饰: Autoproteolytically activated.
    相关疾病 : DISEASE: Parkinson disease 13 (PARK13) [MIM:610297]: A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. {ECO:0000269|PubMed:15961413}. Note=The disease is caused by mutations affecting the gene represented in this entry.
    相似的序列: Belongs to the peptidase S1C family. {ECO:0000305}.; Contains 1 PDZ (DHR) domain. {ECO:0000255|PROSITE-ProRule:PRU00143}.
    General information above from UniProt

    Serine protease HTRA2, also known as high temperature requirement protein A2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI and HTRA2, is a single-pass membrane protein which belongs to the peptidase S1B family. HTRA2 contains one PDZ (DHR) domain. HTRA2 is a serine protease that shows proteolytic activity against a non-specific substrate beta-casein. It promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. HTRA2 cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 of HTRA2 seems to be proteolytically inactive. Defects in HTRA2 are the cause of Parkinson disease type 13 (PARK13) which is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa.

    HtrA2 别称

    OMI,PARK13,PRSS25, [homo-sapiens]
    HtrA2,OMI,PARK13,PRSS25, [human]
    AI481710,HtrA2,mnd2,Omi,Prss25, [mouse]
    Omi,mnd2,Prss25,AI481710, [mus-musculus]

    HtrA2 相关文献

  • Faccio L., et al., 2000, J. Biol. Chem. 275:2581-2588.
  • Gray C.W., et al., 2000, Eur. J. Biochem. 267:5699-5710.
  • Suzuki Y., et al., 2001, Mol. Cell 8:613-621.
  • Strauss K.M., et al., 2005, Hum. Mol. Genet. 14:2099-2111.
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