Text Size:AAA

 IL17RA/IL-17RA/CD217  抗体

All IL-17R Reagents

IL17RA/IL-17RA/CD217
反应性: Human  
应用 : 
10895-R004-F-25
10895-R004-F-100
25 Test 
100 Tests 
Add to Cart
  • Slide 1
反应性: Human  
应用 : 
10895-MM06-A-25
10895-MM06-A-100
25 Test 
100 Tests 
Add to Cart
  • Slide 1
反应性: Human  
应用 : 
10895-MM06-F-25
10895-MM06-F-100
25 Test 
100 Tests 
Add to Cart
  • Slide 1
反应性: Human  
应用 : 
10895-MM06-P-25
10895-MM06-P-100
25 Test 
100 Tests 
Add to Cart
  • Slide 1
反应性: Human  
应用 : ELISA  
10895-T16-50
10895-T16-200
10895-T16-100
50 µg 
200 µg 
100 µg 
Add to Cart
    反应性: Human  
    应用 : WB  
    10895-MM07-50
    10895-MM07-200
    10895-MM07-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    • Slide 1
    反应性: Human  
    应用 : ELISA  
    10895-R012-50
    10895-R012-100
    50 µg 
    100 µg 
    Add to Cart
      反应性: Human  
      应用 : B/N  
      10895-R004-500
      10895-R004-200
      500 µg 
      200 µg 
      Add to Cart
      • Slide 1
      反应性: Human  
      应用 : ELISA  
      10895-MM06-50
      10895-MM06-200
      10895-MM06-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
        反应性: Human  
        应用 : ELISA  
        10895-RP01-400
        10895-RP01-200
        10895-RP01-100
        400 µg 
        200 µg 
        100 µg 
        Add to Cart
          10895-H03HL-300 
          10895-H08HL-300 

          Browse IL17RA/IL-17RA/CD217 Products by

          IL17RA/IL-17RA/CD217 相关研究领域

          IL17RA/IL-17RA/CD217 相关信号通路

            IL17RA/IL-17RA/CD217 相关蛋白、抗体、cDNA基因、ELISA试剂盒

            IL17RA/IL-17RA/CD217 相关蛋白、抗体、cDNA基因、ELISA试剂盒

            Featured Reagent Products

            IL17RA/IL-17RA/CD217 概述&蛋白信息

            IL17RA/IL-17RA/CD217 相关资讯

            IL17RA/IL-17RA/CD217 研究背景

            基因概述: Interleukin 17A (IL17A)is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. [provided by RefSeq, Jul 2008]
            General information above from NCBI
            亚单位结构: Forms heterodimers with IL17RE; the heterodimer binds IL17C. {ECO:0000269|PubMed:19838198}.
            亚细胞定位: Isoform 1: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; Isoform 2: Secreted.
            组织特异性: Widely expressed. {ECO:0000269|PubMed:21993848}.
            翻译后修饰: Glycosylated. {ECO:0000269|PubMed:19838198}.
            相关疾病 : DISEASE: Candidiasis, familial, 5 (CANDF5) [MIM:613953]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269|PubMed:21350122}. Note=The disease is caused by mutations affecting the gene represented in this entry.
            相似的序列: Contains 1 SEFIR domain. {ECO:0000255|PROSITE-ProRule:PRU00867}.
            General information above from UniProt

            Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.

            IL17RA/IL-17RA/CD217 别称

            IL-17RA,CANDF5, []
            CD217,IL17R,CANDF5,CDw217,IL-17RA,hIL-17R, [homo-sapiens]
            CD217,CDw217,hIL-17R,IL17R,IL-17R,IL17RA,MGC10262, [human]
            Cdw217,AW538159,Il17r,Il17ra,VDw217, [mouse]
            Cdw217,Il17r,VDw217,AW538159, [mus-musculus]

            IL17RA/IL-17RA/CD217 相关文献

          • Gaffen SL. (2009) Structure and signalling in the IL-17 receptor family. Nat Rev Immunol. 9 (8): 556-67.
          • Johansen C, et al.. (2009) Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin. Br J Dermatol. 160 (2): 319-24.
          • Yao Z, et al.. (1997) Molecular characterization of the human interleukin (IL)-17 receptor. Cytokine 9 (11): 794-800.
          • 请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”